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A beta(42)/A beta(40) and A beta(42)/A beta(38 ) ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer's disease: a pilot study
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Koychev et al Journal of AD2018.pdf | Published version | 186.95 kB | Adobe PDF | View/Open |
Title: | A beta(42)/A beta(40) and A beta(42)/A beta(38 ) ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer's disease: a pilot study |
Authors: | Koychev, I Galna, B Zetterberg, H Lawson, J Zamboni, G Ridha, BH Rowe, JB Thomas, A Howard, R Malhotra, P Ritchie, C Lovestone, S Rochester, L |
Item Type: | Journal Article |
Abstract: | Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer’s disease (AD) remains to be clarified. In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF. CSF Aβ42/Aβ40 and Aβ42/Aβ38 correlated positively with measures of variability (step time and step length) in the clinic-based assessments. This was driven by a negative relationship between gait variability and Aβ40 and Aβ38 but not Aβ42.The amyloid ratios and gait variability measures were also associated with more severe functional impairment. We interpret these data as an indication that increasing amyloid production (i.e., increasing Aβ40 and Aβ38) is associated with diminishing cognitive-motor control of gait. These preliminary results suggest that the two amyloid ratios may be a marker of the earliest disturbances in the interplay between cognitive and motor control which characterize dementia. |
Issue Date: | 25-Sep-2018 |
Date of Acceptance: | 1-Aug-2018 |
URI: | http://hdl.handle.net/10044/1/64095 |
DOI: | https://dx.doi.org/10.3233/JAD-180622 |
ISSN: | 1387-2877 |
Publisher: | IOS Press |
Start Page: | 1377 |
End Page: | 1383 |
Journal / Book Title: | Journal of Alzheimer's Disease |
Volume: | 65 |
Issue: | 4 |
Copyright Statement: | © 2018 IOS Press and the authors. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY- NC 4.0 - https://creativecommons.org/licenses/by-nc/4.0/). |
Keywords: | Science & Technology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Alzheimer's disease amyloid biomarkers cerebrospinal fluid proteins gait COGNITIVE IMPAIRMENT CEREBROSPINAL-FLUID OLDER-ADULTS PARKINSONS-DISEASE DUAL-TASK DEMENTIA BRAIN VALIDATION SCALE MOTOR Alzheimer’s disease 1103 Clinical Sciences 1702 Cognitive Science 1109 Neurosciences Neurology & Neurosurgery |
Publication Status: | Published |
Online Publication Date: | 2018-09-25 |
Appears in Collections: | Department of Medicine (up to 2019) |