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L-Arginine increases post-prandial circulating GLP-1 and PYY levels in humans

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Title: L-Arginine increases post-prandial circulating GLP-1 and PYY levels in humans
Authors: Amin, A
Neophytou, C
Thein, S
Martin, N
Alamshah, SA
Spreckley, E
Bloom, S
Murphy, KG
Item Type: Journal Article
Abstract: Objective The satiating effect of protein compared with other nutrients has been well described and is thought to be mediated, in part, by gut hormone release. Previously, it has been shown that oral L‐arginine acts as a GLP‐1 secretagogue both in vitro and in vivo in rodents. Here, the effect of L‐arginine on gut hormone release in humans was investigated. Methods The hypothesis was tested in two separate studies. The first study assessed the tolerability of oral L‐arginine in healthy human subjects. The second study assessed the effect of oral L‐arginine on gut hormone release following an ad libitum meal. Subjects were given L‐arginine, glycine (control amino acid), or vehicle control in a randomized double‐blind fashion. Results At a dose of 17.1 mmol, L‐arginine was well tolerated and stimulated the release of plasma GLP‐1 (P < 0.05) and PYY (P < 0.001) following an ad libitum meal. Food diaries showed a trend toward lower energy intake and particularly fat intake following L‐arginine treatment. Conclusions L‐arginine can significantly elevate GLP‐1 and PYY in healthy human volunteers in combination with a meal. Further work is required to investigate whether L‐arginine may have utility in the suppression of appetite and food intake.
Issue Date: 1-Nov-2018
Date of Acceptance: 21-Aug-2018
URI: http://hdl.handle.net/10044/1/63791
DOI: https://dx.doi.org/10.1002/oby.22323
ISSN: 1930-7381
Publisher: Wiley
Start Page: 1721
End Page: 1726
Journal / Book Title: Obesity
Volume: 26
Issue: 11
Copyright Statement: © 2018 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS) This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Medical Research Council (MRC)
Funder's Grant Number: BB/I001816/1
Keywords: MD Multidisciplinary
Endocrinology & Metabolism
Publication Status: Published
Online Publication Date: 2018-10-25
Appears in Collections:Department of Medicine (up to 2019)