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Systematic computation of non-linear cellular and molecular dynamics with low-power cytomimetic circuits: A simulation study
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Title: | Systematic computation of non-linear cellular and molecular dynamics with low-power cytomimetic circuits: A simulation study |
Authors: | Papadimitriou, KI Stan, G-B Drakakis, EM |
Item Type: | Journal Article |
Abstract: | This paper presents a novel method for the systematic implementation of low-power microelectronic circuits aimed at computing nonlinear cellular and molecular dynamics. The method proposed is based on the Nonlinear Bernoulli Cell Formalism (NBCF), an advanced mathematical framework stemming from the Bernoulli Cell Formalism (BCF) originally exploited for the modular synthesis and analysis of linear, time-invariant, high dynamic range, logarithmic filters. Our approach identifies and exploits the striking similarities existing between the NBCF and coupled nonlinear ordinary differential equations (ODEs) typically appearing in models of naturally encountered biochemical systems. The resulting continuous-time, continuous-value, low-power CytoMimetic electronic circuits succeed in simulating fast and with good accuracy cellular and molecular dynamics. The application of the method is illustrated by synthesising for the first time microelectronic CytoMimetic topologies which simulate successfully: 1) a nonlinear intracellular calcium oscillations model for several Hill coefficient values and 2) a gene-protein regulatory system model. The dynamic behaviours generated by the proposed CytoMimetic circuits are compared and found to be in very good agreement with their biological counterparts. The circuits exploit the exponential law codifying the low-power subthreshold operation regime and have been simulated with realistic parameters from a commercially available CMOS process. They occupy an area of a fraction of a square-millimetre, while consuming between 1 and 12 microwatts of power. Simulations of fabrication-related variability results are also presented. |
Issue Date: | 5-Feb-2013 |
Date of Acceptance: | 3-Dec-2012 |
URI: | http://hdl.handle.net/10044/1/63623 |
DOI: | https://dx.doi.org/10.1371/journal.pone.0053591 |
ISSN: | 1932-6203 |
Publisher: | Public Library of Science (PLoS) |
Journal / Book Title: | PLoS ONE |
Volume: | 8 |
Issue: | 2 |
Copyright Statement: | © 2013 Papadimitriou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Sponsor/Funder: | Engineering & Physical Science Research Council (EPSRC) |
Funder's Grant Number: | EP/G036004/1 |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics CA2+-INDUCED CA2+ RELEASE CALCIUM OSCILLATIONS PROTEIN-PHOSPHORYLATION INTRACELLULAR CALCIUM MODEL VLSI Computer Simulation Models, Theoretical Molecular Dynamics Simulation MD Multidisciplinary General Science & Technology |
Publication Status: | Published |
Article Number: | e53591 |
Online Publication Date: | 2013-02-05 |
Appears in Collections: | Bioengineering Faculty of Engineering |