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Uptake and effectiveness of influenza vaccine in those aged 65 years and older in the United Kingdom, influenza seasons 2010/11 to 2016/17

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Title: Uptake and effectiveness of influenza vaccine in those aged 65 years and older in the United Kingdom, influenza seasons 2010/11 to 2016/17
Authors: Pebody, RG
Warburton, F
Andrews, N
Sinnathamby, M
Yonova, I
Reynolds, A
Robertson, C
Cottrell, S
Sartraj, M
Gunson, R
Donati, M
Moore, C
Ellis, J
De Lusignan, S
McMenamin, J
Zambon, M
Item Type: Journal Article
Abstract: Background In 2016/17, seasonal influenza vaccine was less effective in those aged 65 years and older in the United Kingdom. We describe the uptake, influenza-associated mortality and adjusted vaccine effectiveness (aVE) in this age group over influenza seasons 2010/11–2016/17. Methods: Vaccine uptake in 2016/17 and five previous seasons were measured using a sentinel general practitioners cohort in England; the test-negative case-control design was used to estimate pooled aVE by subtype and age group against laboratory-confirmed influenza in primary care from 2010–2017. Results: Vaccine uptake was 64% in 65–69-year-olds, 74% in 70–74-year-olds and 80% in those aged 75 and older. Overall aVE was 32.5% (95% CI: 11.6 to 48.5); aVE by sub-type was 60.8% (95% CI: 33.9 to 76.7) and 50.0% (95% CI: 21.6 to 68.1) against influenza A(H1N1)pdm09 and influenza B, respectively, but only 5.6% (95% CI: - 39.2 to 35.9) against A(H3N2). Against all laboratory-confirmed influenza aVE was 45.2% (95% CI: 25.1 to 60.0) in 65–74 year olds; - 26.2% (95% CI: - 149.3 to 36.0) in 75–84 year olds and - 3.2% (95% CI: - 237.8 to 68.5) in those aged 85 years and older. Influenza-attributable mortality was highest in seasons dominated by A(H3N2). Conclusions: Vaccine uptake with non-adjuvanted, normal-dose vaccines remained high, with evidence of effectiveness against influenza A(H1N1)pdm09 and B, though poor against A(H3N2), particularly in those aged 75 years and older. Forthcoming availability of newly licensed vaccines with wider use of antivirals can potentially further improve prevention and control of influenza in this group.
Issue Date: 27-Sep-2018
Date of Acceptance: 8-Jun-2018
URI: http://hdl.handle.net/10044/1/63598
DOI: https://dx.doi.org/10.2807/1560-7917.ES.2018.23.39.1800092
ISSN: 1560-7917
Publisher: European Centre for Disease Prevention and Control
Start Page: 20
End Page: 29
Journal / Book Title: Eurosurveillance
Volume: 23
Issue: 39
Copyright Statement: © 2018 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
United Kingdom
vaccine uptake and effectiveness
viral infections
Publication Status: Published
Article Number: 1800092
Online Publication Date: 2018-09-07
Appears in Collections:National Heart and Lung Institute