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Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery systems

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Title: Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery systems
Authors: Zhan, W
Alamer, M
Xu, XY
Item Type: Journal Article
Abstract: Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical processes taking place across a wide range of length and time scales. The therapeutic efficacy of anticancer drugs is influenced by the complex interplays among the intrinsic properties of tumours, biophysical aspects of drug transport and cellular uptake. Mathematical and computational modelling allows for a well-controlled study on the individual and combined effects of a wide range of parameters on drug transport and therapeutic efficacy, which would not be possible or economically viable through experimental means. A wide spectrum of mathematical models has been developed for the simulation of drug transport and delivery in solid tumours, including PK/PD-based compartmental models, microscopic and macroscopic transport models, and molecular dynamics drug loading and release models. These models have been used as a tool to identify the limiting factors and for optimal design of efficient drug delivery systems. This article gives an overview of the currently available computational models for drug transport in solid tumours, together with their applications to novel drug delivery systems, such as nanoparticle-mediated drug delivery and convection-enhanced delivery.
Issue Date: 29-Jul-2018
Date of Acceptance: 20-Jul-2018
URI: http://hdl.handle.net/10044/1/62926
DOI: https://dx.doi.org/10.1016/j.addr.2018.07.013
ISSN: 0169-409X
Publisher: Elsevier
Start Page: 81
End Page: 103
Journal / Book Title: Advanced Drug Delivery Reviews
Volume: 132
Copyright Statement: © 2018 Elsevier B.V. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Cancer
Drug delivery system
Drug transport
Mathematical modelling
1115 Pharmacology And Pharmaceutical Sciences
Pharmacology & Pharmacy
Publication Status: Published
Conference Place: Netherlands
Online Publication Date: 2018-07-29
Appears in Collections:Mechanical Engineering
Chemical Engineering
Faculty of Engineering