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Cardiomyopathies and related changes in contractility of human heart muscle

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Title: Cardiomyopathies and related changes in contractility of human heart muscle
Authors: Vikhorev, P
Vikhoreva, N
Item Type: Journal Article
Abstract: About half of hypertrophic and dilated cardiomyopathies cases have been recognized as genetic diseases with mutations in sarcomeric proteins. The sarcomeric proteins are involved in cardiomyocyte contractility and its regulation, and play a structural role. Mutations in non-sarcomeric proteins may induce changes in cell signaling pathways that modify contractile response of heart muscle. These facts strongly suggest that contractile dysfunction plays a central role in initiation and progression of cardiomyopathies. In fact, abnormalities in contractile mechanics of myofibrils have been discovered. However, it has not been revealed how these mutations increase risk for cardiomyopathy and cause the disease. Much research has been done and still much is being done to understand how the mechanism works. Here, we review the facts of cardiac myofilament contractility in patients with cardiomyopathy and heart failure.
Issue Date: 31-Jul-2018
Date of Acceptance: 27-Jul-2018
URI: http://hdl.handle.net/10044/1/62693
DOI: https://dx.doi.org/10.3390/ijms19082234
ISSN: 1422-0067
Publisher: MDPI AG
Journal / Book Title: International Journal of Molecular Sciences
Volume: 19
Issue: 8
Copyright Statement: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: PG/17/5/32705
Keywords: 0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
Chemical Physics
Publication Status: Published
Open Access location: http://www.mdpi.com/1422-0067/19/8/2234/pdf
Article Number: 2234
Appears in Collections:National Heart and Lung Institute