Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits

Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsud, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrera, CP; Karaman, I; Fu, LN; Evangelou, M; Witkowska, K; Tzanis, E; Hellwege, JN; Giri, A; Edwards, DRV; Sun, YV; Cho, K; Gaziano, JM; Wilson, PWF; Tsao, PS; Kovesdy, CP; Esko, T; Magi, R; Milani, L; Almgren, P; Boutin, T; Debette, S; Ding, J; Giulianini, F; Holliday, EG; Jackson, AU; Li-Gao, R; Lin, W-Y; Luan, J; Mangino, M; Oldmeadow, C; Prins, BP; Qian, Y; Sargurupremraj, M; Shah, N; Surendran, P; Theriault, S; Verweij, N; Willems, SM; Zhao, J-H; Amouyel, P; Connell, J; De Mutsert, R; Doney, ASF; Farrall, M; Menni, C; Morris, AD; Noordam, R; Pare, G; Poulter, NR; Shields, DC; Stanton, A; Thom, S; Abecasis, G; Amin, N; Arking, DE; Ayers, KL; Barbieri, CM; Batini, C; Bis, JC; Blake, T; Bochud, M; Boehnke, M; Boerwinkle, E; Boomsma, DI; Bottinger, EP; Braund, PS; Brumat, M; Campbell, A; Campbell, H; Chakravarti, A; Chambers, JC; Chauhan, G; Ciullo, M; Cocca, M; Collins, F; Cordell, HJ; Davies, G; De Borst, MH; De Geus, EJ; Deary, IJ; Deelen, J; Del Greco, FM; Demirkale, CY; Dorr, M; Ehret, GB; Elosua, R; Enroth, S; Erzurumluoglu, AM; Ferreira, T; Franberg, M; Franco, OH; Gandin, I; Gasparini, P; Giedraitis, V; Gieger, C; Girotto, G; Goel, A; Gow, AJ; Gudnason, V; Guo, X; Gyllensten, U; Hamsten, A; Harris, TB; Harris, SE; Hartman, CA; Havulinna, AS; Hicks, AA; Hofer, E; Hofman, A; Hottenga, J-J; Huffman, JE; Hwang, S-J; Ingelsson, E; James, A; Jansen, R; Jarvelin, M-R; Joehanes, R; Johansson, A; Johnson, AD; Joshi, PK; Jousilahti, P; Jukema, JW; Jula, A; Kahonen, M; Kathiresan, S; Keavney, BD; Khaw, K-T; Knekt, P; Knight, J; Kolcic, I; Kooner, JS; Koskinen, S; Kristiansson, K; Kutalik, Z; Laan, M; Larson, M; Launer, LJ; Lehne, B; Lehtimaki, T; Liewald, DCM; Lin, L; Lind, L; Lindgren, CM; Liu, Y; Loos, RJF; Lopez, LM; Lu, Y; Lyytikainen, L-P; Mahajan, A; Mamasoula, C; Marrugat, J; Marten, J; Milaneschi, Y; Morgan, A; Morris, AP; Morrison, AC; Munson, PJ; Nalls, MA; Nandakumar, P; Nelson, CP; Niiranen, T; Nolte, IM; Nutile, T; Oldehinkel, AJ; Oostra, BA; O'Reilly, PF; Org, E; Padmanabhan, S; Palmas, W; Palotie, A; Pattie, A; Penninx, BWJH; Perola, M; Peters, A; Polasek, O; Pramstaller, PP; Quang, TN; Raitakari, OT; Ren, M; Rettig, R; Rice, K; Ridker, PM; Ried, JS; Riese, H; Ripatti, S; Robino, A; Rose, LM; Rotter, JI; Rudan, I; Ruggiero, D; Saba, Y; Sala, CF; Salomaa, V; Samani, NJ; Sarin, A-P; Schmidt, R; Schmidt, H; Shrine, N; Siscovick, D; Smith, AV; Snieder, H; Sober, S; Sorice, R; Starr, JM; Stott, DJ; Strachan, DP; Strawbridge, RJ; Sundstrom, J; Swertz, MA; Taylor, KD; Teumer, A; Tobin, MD; Tomaszewski, M; Toniolo, D; Traglia, M; Trompet, S; Tuomilehto, J; Tzourio, C; Uitterlinden, AG; Vaez, A; Van der Most, PJ; Van Duijn, CM; Vergnaud, A-C; Verwoert, GC; Vitart, V; Volker, U; Vollenweider, P; Vuckovic, D; Watkins, H; Wild, SH; Willemsen, G; Wilson, JF; Wright, AF; Yao, J; Zemunik, T; Zhang, W; Attia, JR; Butterworth, AS; Chasman, DI; Conen, D; Cucca, F; Danesh, J; Hayward, C; Howson, JMM; Laakso, M; Lakatta, EG; Langenberg, C; Melander, O; Mook-Kanamori, DO; Palmer, CNA; Risch, L; Scott, RA; Scott, RJ; Sever, P; Spector, TD; Van der Harst, P; Wareham, NJ; Zeggini, E; Levy, D; Munroe, PB; Newton-Cheh, C; Brown, MJ; Metspalu, A; Hung, AM; O'Donnell, CJ; Edwards, TL; Psaty, BM; Tzoulaki, I; Barnes, MR; Wain, LV; Elliott, P; Caulfield, MJ

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Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits

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Title:	Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits
Authors:	Evangelou, E Warren, HR Mosen-Ansorena, D Mifsud, B Pazoki, R Gao, H Ntritsos, G Dimou, N Cabrera, CP Karaman, I Fu, LN Evangelou, M Witkowska, K Tzanis, E Hellwege, JN Giri, A Edwards, DRV Sun, YV Cho, K Gaziano, JM Wilson, PWF Tsao, PS Kovesdy, CP Esko, T Magi, R Milani, L Almgren, P Boutin, T Debette, S Ding, J Giulianini, F Holliday, EG Jackson, AU Li-Gao, R Lin, W-Y Luan, J Mangino, M Oldmeadow, C Prins, BP Qian, Y Sargurupremraj, M Shah, N Surendran, P Theriault, S Verweij, N Willems, SM Zhao, J-H Amouyel, P Connell, J De Mutsert, R Doney, ASF Farrall, M Menni, C Morris, AD Noordam, R Pare, G Poulter, NR Shields, DC Stanton, A Thom, S Abecasis, G Amin, N Arking, DE Ayers, KL Barbieri, CM Batini, C Bis, JC Blake, T Bochud, M Boehnke, M Boerwinkle, E Boomsma, DI Bottinger, EP Braund, PS Brumat, M Campbell, A Campbell, H Chakravarti, A Chambers, JC Chauhan, G Ciullo, M Cocca, M Collins, F Cordell, HJ Davies, G De Borst, MH De Geus, EJ Deary, IJ Deelen, J Del Greco, FM Demirkale, CY Dorr, M Ehret, GB Elosua, R Enroth, S Erzurumluoglu, AM Ferreira, T Franberg, M Franco, OH Gandin, I Gasparini, P Giedraitis, V Gieger, C Girotto, G Goel, A Gow, AJ Gudnason, V Guo, X Gyllensten, U Hamsten, A Harris, TB Harris, SE Hartman, CA Havulinna, AS Hicks, AA Hofer, E Hofman, A Hottenga, J-J Huffman, JE Hwang, S-J Ingelsson, E James, A Jansen, R Jarvelin, M-R Joehanes, R Johansson, A Johnson, AD Joshi, PK Jousilahti, P Jukema, JW Jula, A Kahonen, M Kathiresan, S Keavney, BD Khaw, K-T Knekt, P Knight, J Kolcic, I Kooner, JS Koskinen, S Kristiansson, K Kutalik, Z Laan, M Larson, M Launer, LJ Lehne, B Lehtimaki, T Liewald, DCM Lin, L Lind, L Lindgren, CM Liu, Y Loos, RJF Lopez, LM Lu, Y Lyytikainen, L-P Mahajan, A Mamasoula, C Marrugat, J Marten, J Milaneschi, Y Morgan, A Morris, AP Morrison, AC Munson, PJ Nalls, MA Nandakumar, P Nelson, CP Niiranen, T Nolte, IM Nutile, T Oldehinkel, AJ Oostra, BA O'Reilly, PF Org, E Padmanabhan, S Palmas, W Palotie, A Pattie, A Penninx, BWJH Perola, M Peters, A Polasek, O Pramstaller, PP Quang, TN Raitakari, OT Ren, M Rettig, R Rice, K Ridker, PM Ried, JS Riese, H Ripatti, S Robino, A Rose, LM Rotter, JI Rudan, I Ruggiero, D Saba, Y Sala, CF Salomaa, V Samani, NJ Sarin, A-P Schmidt, R Schmidt, H Shrine, N Siscovick, D Smith, AV Snieder, H Sober, S Sorice, R Starr, JM Stott, DJ Strachan, DP Strawbridge, RJ Sundstrom, J Swertz, MA Taylor, KD Teumer, A Tobin, MD Tomaszewski, M Toniolo, D Traglia, M Trompet, S Tuomilehto, J Tzourio, C Uitterlinden, AG Vaez, A Van der Most, PJ Van Duijn, CM Vergnaud, A-C Verwoert, GC Vitart, V Volker, U Vollenweider, P Vuckovic, D Watkins, H Wild, SH Willemsen, G Wilson, JF Wright, AF Yao, J Zemunik, T Zhang, W Attia, JR Butterworth, AS Chasman, DI Conen, D Cucca, F Danesh, J Hayward, C Howson, JMM Laakso, M Lakatta, EG Langenberg, C Melander, O Mook-Kanamori, DO Palmer, CNA Risch, L Scott, RA Scott, RJ Sever, P Spector, TD Van der Harst, P Wareham, NJ Zeggini, E Levy, D Munroe, PB Newton-Cheh, C Brown, MJ Metspalu, A Hung, AM O'Donnell, CJ Edwards, TL Psaty, BM Tzoulaki, I Barnes, MR Wain, LV Elliott, P Caulfield, MJ
Item Type:	Journal Article
Abstract:	High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Issue Date:	17-Sep-2018
Date of Acceptance:	9-Jul-2018
URI:	http://hdl.handle.net/10044/1/62366
DOI:	10.1038/s41588-018-0205-x
ISSN:	1061-4036
Publisher:	Nature Publishing Group
Start Page:	1412
End Page:	1425
Journal / Book Title:	Nature Genetics
Volume:	50
Issue:	10
Replaces:	10044/1/70810 http://hdl.handle.net/10044/1/70810
Copyright Statement:	© 2019 Springer Nature Limited.
Sponsor/Funder:	UNIVERSITY OF OULU Commission of the European Communities Home Office Action on Hearing Loss Imperial College Healthcare NHS Trust- BRC Funding National Institute for Health Research British Heart Foundation Medical Research Council (MRC) Medical Research Council (MRC) Medical Research Council (MRC) Medical Research Council (MRC) UK DRI Ltd National Institute for Health Research National Institute for Health Research Medical Research Council (MRC)
Funder's Grant Number:	Nil 201413 PG0484 G51_Chambers RDF03 RTJ6219303-1 SP/13/2/30111 MR/L01341X/1 G0601966 MR/L01632X/1 MR/L01632X/1 4050641385 NF-SI-0513-10059 NF-SI-0513-10059 MR/R023484/1
Keywords:	Science & Technology Life Sciences & Biomedicine Genetics & Heredity GENOME-WIDE ASSOCIATION CARDIOVASCULAR RISK HYPERTENSION VARIANTS METAANALYSIS COMMON HEALTH RARE HYPERALDOSTERONISM PREVALENCE Adult Aged Aged, 80 and over Blood Pressure Cardiovascular Diseases Cells, Cultured Female Genetic Loci Genetic Predisposition to Disease Genetic Testing Genetics, Population Genome-Wide Association Study Human Umbilical Vein Endothelial Cells Humans Hypertension Life Style Male Middle Aged Polymorphism, Single Nucleotide Quantitative Trait Loci Risk Factors Million Veteran Program Cells, Cultured Humans Cardiovascular Diseases Hypertension Genetic Predisposition to Disease Risk Factors Life Style Genetics, Population Blood Pressure Polymorphism, Single Nucleotide Quantitative Trait Loci Adult Aged Aged, 80 and over Middle Aged Female Male Genome-Wide Association Study Genetic Testing Genetic Loci Human Umbilical Vein Endothelial Cells 06 Biological Sciences 11 Medical and Health Sciences Developmental Biology
Publication Status:	Published
Online Publication Date:	2018-09-17
Appears in Collections:	Statistics National Heart and Lung Institute Faculty of Medicine School of Public Health Faculty of Natural Sciences Mathematics