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Macrophage- but not monocyte-derived extracellular vesicles induce placental pro-inflammatory responses

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Rice et al. Placenta 2018 Accepted Sympletics.docxAccepted version1.07 MBMicrosoft WordView/Open
Title: Macrophage- but not monocyte-derived extracellular vesicles induce placental pro-inflammatory responses
Authors: Rice, T
Donaldson, B
Bouqueau, M
Kampmann, B
Holder, B
Item Type: Journal Article
Abstract: The placenta sheds extracellular vesicles (EVs), including exosomes, into the maternal circulation. We recently demonstrated that this trafficking of EVs is bi‐directional; with uptake of macrophage exosomes by the placenta inducing cytokine release. The specificity of this response is currently unknown. THP-1 cells were cultured as monocytes or differentiated to macrophages, and EVs isolated by ultra-centrifugation. The effect of EVs on human placental explants was measured by cytokine ELISA/luminex. Macrophage, but not monocyte, EVs induce the release of pro-inflammatory cytokines by the placenta. Thus, placental responses to immune cell EVs, including exosomes, reflects the phenotype of the source cell.
Issue Date: 1-Sep-2018
Date of Acceptance: 19-Jul-2018
URI: http://hdl.handle.net/10044/1/62337
DOI: https://dx.doi.org/10.1016/j.placenta.2018.07.011
ISSN: 0143-4004
Publisher: Elsevier
Start Page: 92
End Page: 95
Journal / Book Title: Placenta
Volume: 69
Copyright Statement: © 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Newlife Foundation for Disabled Children
Newlife Foundation for Disabled Children
MRC The Gambia
Medical Research Council
NIHR Imperial BRC
NIHR Imperial BRC
Funder's Grant Number: SG/12-13/05
MRC The Gambia Secondment for Beate Kampmann
MC_UP_A900/1122
P72781
Keywords: 1103 Clinical Sciences
1114 Paediatrics And Reproductive Medicine
Obstetrics & Reproductive Medicine
Publication Status: Published
Online Publication Date: 2018-07-24
Appears in Collections:Department of Medicine (up to 2019)



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