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microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma

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Title: microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma
Authors: Ottaviani, S
Castellano, L
Item Type: Journal Article
Abstract: We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.
Issue Date: 13-Aug-2018
Date of Acceptance: 7-Jul-2018
URI: http://hdl.handle.net/10044/1/62177
DOI: 10.1080/23723556.2018.1499066
ISSN: 2372-3556
Publisher: Taylor & Francis
Start Page: 1
End Page: 3
Journal / Book Title: Molecular & Cellular Oncology
Volume: 5
Issue: 6
Copyright Statement: © 2018 Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Molecular and Cellular Oncology on 13 August 2018, available online: https://doi.org/10.1080/23723556.2018.1499066
Sponsor/Funder: Pancreatic Cancer UK
Imperial College Trust
Funder's Grant Number: N/A
N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
TGF-beta
microRNAs
miR-100
miR-125b
let-7
EMT
CSC
stemness
metastasis
PDAC
CANCER
TUMORIGENICITY
ZEB1
CSC
EMT
PDAC
TGF-β
let-7
metastasis
miR-100
miR-125b
microRNAs
stemness
Publication Status: Published
Online Publication Date: 2018-08-13
Appears in Collections:Department of Surgery and Cancer