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microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma
| File | Description | Size | Format | |
|---|---|---|---|---|
 Author's Views revision.docx | Accepted version | 48.62 kB | Microsoft Word | View/Open |
| Title: | microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma |
| Authors: | Ottaviani, S Castellano, L |
| Item Type: | Journal Article |
| Abstract: | We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways. |
| Issue Date: | 13-Aug-2018 |
| Date of Acceptance: | 7-Jul-2018 |
| URI: | http://hdl.handle.net/10044/1/62177 |
| DOI: | 10.1080/23723556.2018.1499066 |
| ISSN: | 2372-3556 |
| Publisher: | Taylor & Francis |
| Start Page: | 1 |
| End Page: | 3 |
| Journal / Book Title: | Molecular & Cellular Oncology |
| Volume: | 5 |
| Issue: | 6 |
| Copyright Statement: | © 2018 Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Molecular and Cellular Oncology on 13 August 2018, available online: https://doi.org/10.1080/23723556.2018.1499066 |
| Sponsor/Funder: | Pancreatic Cancer UK Imperial College Trust |
| Funder's Grant Number: | N/A N/A |
| Keywords: | Science & Technology Life Sciences & Biomedicine Oncology TGF-beta microRNAs miR-100 miR-125b let-7 EMT CSC stemness metastasis PDAC CANCER TUMORIGENICITY ZEB1 CSC EMT PDAC TGF-β let-7 metastasis miR-100 miR-125b microRNAs stemness |
| Publication Status: | Published |
| Online Publication Date: | 2018-08-13 |
| Appears in Collections: | Department of Surgery and Cancer |