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Type 2 immunity: expanding our view.

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Title: Type 2 immunity: expanding our view.
Authors: Lloyd, CM
Snelgrove, RJ
Item Type: Journal Article
Abstract: The classical vision of type 2 immune reactions is that they are characterized by a distinct cellular and cytokine repertoire that is critical for host resistance against helminthic worm infections but, when dysregulated, may cause atopic reactions that result in conditions such as asthma, rhinitis, dermatitis, and anaphylaxis. In this traditional view, the type 2 response is categorized as an adaptive immune response with differentiated T helper cells taking center stage, driving eosinophil recruitment and immunoglobulin production via the secretion of a distinct repertoire of cytokines that include interleukin-4 (IL-4), IL-5, and IL-13. The recent discovery of a group of innate cells that has the capacity to secrete copious amounts of type 2 cytokines, potentially in the absence of adaptive immunity, has reignited interest in type 2 biology. The discovery that these innate lymphoid cells and type 2 cytokines are involved in diverse biological processes-including wound healing, control of metabolic homeostasis, and temperature-has considerably changed our view of type 2 responses and the cytokines, chemokines, and receptors that regulate these responses.
Issue Date: 6-Jul-2018
Date of Acceptance: 30-May-2018
URI: http://hdl.handle.net/10044/1/61948
DOI: https://dx.doi.org/10.1126/sciimmunol.aat1604
ISSN: 2470-9468
Publisher: American Association for the Advancement of Science
Journal / Book Title: Science Immunology
Volume: 3
Issue: 25
Copyright Statement: © 2018 TheAuthors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works by guest on August 30, 2018http://immunology.sciencemag.org/Downloaded from
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Funder's Grant Number: 107059/Z/15/Z
Publication Status: Published
Conference Place: United States
Article Number: eaat1604
Appears in Collections:National Heart and Lung Institute