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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
| File | Description | Size | Format | |
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 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.pdf | Accepted version | 993.3 kB | Adobe PDF | View/Open |
| Title: | Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure |
| Authors: | Wain, LV Verwoert, GC O'Reilly, PF Shi, G Johnson, T Johnson, AD Bochud, M Rice, KM Henneman, P Smith, AV Ehret, GB Amin, N Larson, MG Mooser, V Hadley, D Doerr, M Bis, JC Aspelund, T Esko, T Janssens, ACJW Zhao, JH Heath, S Laan, M Fu, J Pistis, G Luan, J Arora, P Lucas, G Pirastu, N Pichler, I Jackson, AU Webster, RJ Zhang, F Peden, JF Schmidt, H Tanaka, T Campbell, H Igl, W Milaneschi, Y Hottenga, J-J Vitart, V Chasman, DI Trompet, S Bragg-Gresham, JL Alizadeh, BZ Chambers, JC Guo, X Lehtimaki, T Kuehnel, B Lopez, LM Polasek, O Boban, M Nelson, CP Morrison, AC Pihur, V Ganesh, SK Hofman, A Kundu, S Mattace-Raso, FUS Rivadeneira, F Sijbrands, EJG Uitterlinden, AG Hwang, S-J Vasan, RS Wang, TJ Bergmann, S Vollenweider, P Waeber, G Laitinen, J Pouta, A Zitting, P McArdle, WL Kroemer, HK Voelker, U Voelzke, H Glazer, NL Taylor, KD Harris, TB Alavere, H Haller, T Keis, A Tammesoo, M-L Aulchenko, Y Barroso, I Khaw, K-T Galan, P Hercberg, S Lathrop, M Eyheramendy, S Org, E Sober, S Lu, X Nolte, IM Penninx, BW Corre, T Masciullo, C Sala, C Groop, L Voight, BF Melander, O O'Donnell, CJ Salomaa, V D'Adamo, AP Fabretto, A Faletra, F Ulivi, S Del Greco, FM Facheris, M Collins, FS Bergman, RN Beilby, JP Hung, J Musk, AW Mangino, M Shin, S-Y Soranzo, N Watkins, H Goel, A Hamsten, A Gider, P Loitfelder, M Zeginigg, M Hernandez, D Najjar, SS Navarro, P Wild, SH Corsi, AM Singleton, A De Geus, EJC Willemsen, G Parker, AN Rose, LM Buckley, B Stott, D Orru, M Uda, M Van der Klauw, MM Zhang, W Li, X Scott, J Chen, Y-DI Burke, GL Kahonen, M Viikari, J Doering, A Meitinger, T Davies, G Starr, JM Emilsson, V Plump, A Lindeman, JH 't Hoen, PAC Koenig, IR Felix, JF Clarke, R Hopewell, JC Ongen, H Breteler, M Debette, S DeStefano, AL Fornage, M Mitchell, GF Smith, NL Holm, H Stefansson, K Thorleifsson, G Thorsteinsdottir, U Samani, NJ Preuss, M Rudan, I Hayward, C Deary, IJ Wichmann, H-E Raitakari, OT Palmas, W Kooner, JS Stolk, RP Jukema, JW Wright, AF Boomsma, DI Bandinelli, S Gyllensten, UB Wilson, JF Ferrucci, L Schmidt, R Farrall, M Spector, TD Palmer, LJ Tuomilehto, J Pfeufer, A Gasparini, P Siscovick, D Altshuler, D Loos, RJF Toniolo, D Snieder, H Gieger, C Meneton, P Wareham, NJ Oostra, BA Metspalu, A Launer, L Rettig, R Strachan, DP Beckmann, JS Witteman, JCM Erdmann, J Van Dijk, KW Boerwinkle, E Boehnke, M Ridker, PM Jarvelin, M-R Chakravarti, A Abecasis, GR Gudnason, V Newton-Cheh, C Levy, D Munroe, PB Psaty, BM Caulfield, MJ Rao, DC Tobin, MD Elliott, P Van Duijn, CM |
| Item Type: | Journal Article |
| Abstract: | Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans1,2,3. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10−8 to P = 2.3 × 10−13) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP. |
| Issue Date: | 11-Sep-2011 |
| Date of Acceptance: | 4-Aug-2011 |
| URI: | http://hdl.handle.net/10044/1/61810 |
| DOI: | https://dx.doi.org/10.1038/ng.922 |
| ISSN: | 1061-4036 |
| Publisher: | NATURE PUBLISHING GROUP |
| Start Page: | 1005 |
| End Page: | U122 |
| Journal / Book Title: | NATURE GENETICS |
| Volume: | 43 |
| Issue: | 10 |
| Copyright Statement: | © 2011 Nature America, Inc. All rights reserved. The final publication is available at https://dx.doi.org/10.1038/ng.922 |
| Sponsor/Funder: | Medical Research Council (MRC) Medical Research Council (MRC) Medical Research Council (MRC) Medical Research Council (MRC) |
| Funder's Grant Number: | G0700931 G0601966 G0801056B G0801056 |
| Keywords: | Science & Technology Life Sciences & Biomedicine Genetics & Heredity ADRENERGIC-RECEPTOR TRAFFICKING CARDIOVASCULAR-DISEASE RISK BLOOD-PRESSURE HEART-FAILURE HYPERTENSION METAANALYSIS MORTALITY GENE MICE RELEVANCE Arteries Blood Pressure Case-Control Studies Follow-Up Studies Genetic Loci Genome-Wide Association Study Humans Hypertension Linkage Disequilibrium Polymorphism, Single Nucleotide LifeLines Cohort Study EchoGen consortium AortaGen Consortium CHARGE Consortium Heart Failure Working Group KidneyGen consortium CKDGen consortium Cardiogenics consortium CardioGram 11 Medical And Health Sciences 06 Biological Sciences Developmental Biology |
| Publication Status: | Published |
| Online Publication Date: | 2011-09-11 |
| Appears in Collections: | Department of Medicine (up to 2019) |