A 12.8 k current-mode velocity-saturation ISFET array for on-chip real-time DNA detection

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Title: A 12.8 k current-mode velocity-saturation ISFET array for on-chip real-time DNA detection
Authors: Miscourides, N
Yu, L-S
Rodriguez-Manzano, J
Georgiou, P
Item Type: Journal Article
Abstract: This paper presents a large-scale CMOS chemical-sensing array operating in current mode for real-time ion imaging and detection of DNA amplification. We show that the current-mode operation of ion-sensitive field-effect transistors in velocity saturation devices can be exploited to achieve an almost perfect linearity in their input-output characteristics (pH-current), which are aligned with the continuous scaling trend of transistors in CMOS. The array is implemented in a 0.35-m process and includes 12.8 k sensors configured in a 2T per pixel topology. We characterize the array by taking into account nonideal effects observed with floating gate devices, such as increased pixel mismatch due to trapped charge and attenuation of the input signal due to the passivation capacitance, and show that the selected biasing regime allows for a sufficiently large linear range that ensures a linear pH to current despite the increased mismatch. The proposed system achieves a sensitivity of 1.03 A/pH with a pH resolution of 0.101 pH and is suitable for the real-time detection of the NDM carbapenemase gene in E. Coli using a loop-mediated isothermal amplification.
Issue Date: 16-Jul-2018
Date of Acceptance: 25-Jun-2018
ISSN: 1932-4545
Publisher: Institute of Electrical and Electronics Engineers
Journal / Book Title: IEEE Transactions on Biomedical Circuits and Systems
Copyright Statement: © 2018 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See standards/publications/rights/index.html for more information.
Sponsor/Funder: Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/P510798/1
Keywords: 0903 Biomedical Engineering
0906 Electrical And Electronic Engineering
Electrical & Electronic Engineering
Publication Status: Published online
Conference Place: United States
Online Publication Date: 2018-07-16
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering

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