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Nonmyeloablative allogeneic stem-cell transplantation for metastatic renal cell cancer: a review and update

Title: Nonmyeloablative allogeneic stem-cell transplantation for metastatic renal cell cancer: a review and update
Authors: Erotocritou, P
Ahmed, H
Patel, SS
Shergill, I
Patel, HR
Shah, PM
Arya, M
Item Type: Journal Article
Abstract: Metastatic renal cell carcinoma (RCC) is resistant to conventional chemotherapy and radiotherapy. However, immunotherapy appears to be effective in 15–20% of cases, with interleukin-2 becoming the standard therapy for this disease. As a consequence of the immune susceptibility of RCC, other avenues of immunotherapy are being explored, such as nonmyeloablative allogeneic stem cell transplantation (NST). A number of trials have shown NST to be effective in varying degrees, causing partial or complete regression. Although nonmyeloablative conditioning is safer than myeloablative conditioning, its role has yet to be clearly proven as many studies have shown variable effect. Alongside this limitation, transplant-related toxicity also forms obstacles. Regardless of the limitation of NST, further refinement of the technique, with appropriate patient selection, may lead to this being an effective therapeutic choice for a significant number of individuals.
Issue Date: 15-Dec-2006
Date of Acceptance: 29-Nov-2006
URI: http://hdl.handle.net/10044/1/60938
DOI: https://dx.doi.org/10.1100/tsw.2006.391
ISSN: 1537-744X
Publisher: Hindawi Publishing Corporation
Start Page: 2519
End Page: 2528
Journal / Book Title: The Scientific World Journal
Volume: 6
Copyright Statement: © 2006 P. Erotocritou et al.
Keywords: Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Multidisciplinary Sciences
Environmental Sciences & Ecology
Science & Technology - Other Topics
allogeneic stem cell
metastatic renal cell cancer
myeloablative
nonmyeloablative
immunotherapy
PHASE-II TRIAL
BONE-MARROW-TRANSPLANTATION
INTENSITY CONDITIONING REGIMEN
CHEMOIMMUNOTHERAPY GROUP DGCIN
REDUCED-INTENSITY
INTERFERON-ALPHA
13-CIS-RETINOIC ACID
BREAST-CANCER
HEMATOLOGIC MALIGNANCIES
SPONTANEOUS REGRESSION
Animals
Carcinoma, Renal Cell
Clinical Trials as Topic
Humans
Immunotherapy
Kidney Neoplasms
Neoplasm Metastasis
Stem Cell Transplantation
Stem Cells
Treatment Outcome
General Science & Technology
Publication Status: Published
Online Publication Date: 2006-12-15
Appears in Collections:Department of Surgery and Cancer