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Sensory profiling in animal models of neuropathic pain: a call for back-translation.

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Title: Sensory profiling in animal models of neuropathic pain: a call for back-translation.
Authors: Rice, ASC
Finnerup, NB
Kemp, HI
Currie, GL
Baron, R
Item Type: Journal Article
Abstract: This Topical review considers the misalignment between outcome measures traditionally reported in animal models of neuropathic pain (For brevity, we will adhere to convention and use the shorthand “animal model of neuropathic pain.” However, we suggest that a more accurate classification is in terms of the disease they purportedly mimic [eg, traumatic nerve injury, diabetic neuropathy, etc] rather than as a model of “pain.”) and those used for estimating pain intensity and the impact/burden of pain in clinical trials. In particular, we propose that traditional methods of assessing rodent sensory thresholds could have predictive utility for the sensory profiling approaches being explored for patient stratification in clinical trials. To initiate this process, we propose a “research agenda” to develop and validate a protocol and normative values for sensory profiling in rodents, which reflects the best established clinical methods. This could then be used to establish definitive sensory profiles of new and existing rodent neuropathic pain models. In general, animal modelling of neuropathic pain has 2 main goals: First, to identify pain mechanisms and thus potential targets for drug development. However, it is difficult to identify clear examples of the success of this approach in delivering new drugs for neuropathic pain, with the exception of high concentration topical capsaicin.22 Second, animal models are used in an attempt to predict the clinical efficacy of a novel therapeutic and thus justify the initiation of clinical trials. We concentrate on the latter aspect and ask whether the drug response associated with specific sensory profiles in animal models might predict the most appropriate patients to examine in exploratory clinical trials?
Issue Date: 1-May-2018
Date of Acceptance: 20-Dec-2017
URI: http://hdl.handle.net/10044/1/60905
DOI: https://dx.doi.org/10.1097/j.pain.0000000000001138
ISSN: 0304-3959
Publisher: Lippincott, Williams & Wilkins
Start Page: 819
End Page: 824
Journal / Book Title: PAIN
Volume: 159
Issue: 5
Copyright Statement: © 2018 International Association for the Study of Pain. This is a non-final version of an article published in final form in PAIN. 159(5):819–824, MAY 2018, https://dx.doi.org/10.1097/j.pain.0000000000001138
Sponsor/Funder: Wellcome Trust
Commission of the European Communities
Funder's Grant Number: WELLCOME GRANT 065374/Z/01/Z
115007
Keywords: 11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Anesthesiology
Publication Status: Published
Conference Place: United States
Online Publication Date: 2017-12-26
Appears in Collections:Department of Surgery and Cancer