A preliminary study of microRNA-208b after acute myocardial infarction: impact on 6-months survival

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Title: A preliminary study of microRNA-208b after acute myocardial infarction: impact on 6-months survival
Authors: Alavi-Moghaddam, M
Chehrazi, M
Alipoor, SD
Mohammadi, M
Baratloo, A
Mahjoub, MP
Movasaghi, M
Garssen, J
Adcock, IM
Mortaz, E
Item Type: Journal Article
Abstract: miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis. Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease. microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis. In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients. Methods. Plasma samples from 21 patients and 8 age- and gender-matched healthy adults were collected, and circulating levels of miR-208b were detected using quantitative real-time PCR. Results. miR-208b levels were higher in healthy control subjects (9.6-fold; ). Within the AMI patients, the levels of miR-208b were significantly lower in the survivor versus nonsurvivor group (fold change = 6.51 and 14.1, resp.; ). The Kaplan-Meier curve revealed that the 6-month survival time was significantly higher among AMI patients with a relative expression of miR-208b lower than 12.38. The hazard ratio (HR) for the relative expression of miR-208b (<12.38 was the reference) was 5.08 (95% CI: 1.13–22.82; ). Conclusion. Our results showed that elevated miR-208b expression was associated with reduced long-term survival in AMI patients. These pilot data indicate the need for a large follow-up study to confirm whether miR-208b can be used as a predictor of 6-month survival time after AMI.
Issue Date: 27-May-2018
Date of Acceptance: 23-Apr-2018
URI: http://hdl.handle.net/10044/1/60088
DOI: https://dx.doi.org/10.1155/2018/2410451
ISSN: 0278-0240
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Disease Markers
Volume: 2018
Copyright Statement: © 2018 Mostafa Alavi-Moghaddam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 093080/Z/10/Z
Keywords: 1116 Medical Physiology
Oncology & Carcinogenesis
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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