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Consensus guidelines for the use and interpretation of angiogenesis assays
| File | Description | Size | Format | |
|---|---|---|---|---|
 consensus paper compressed.pdf | Published version | 3.19 MB | Adobe PDF | View/Open |
| Title: | Consensus guidelines for the use and interpretation of angiogenesis assays |
| Authors: | Nowak-Sliwinska, P Alitalo, K Allen, E Anisimov, A Aplin, AC Auerbach, R Augustin, HG Bates, DO Van Beijnum, JR Bender, RHF Bergers, G Bikfalvi, A Bischoff, J Böck, BC Brooks, PC Bussolino, F Cakir, B Carmeliet, P Castranova, D Cimpean, AM Cleaver, O Coukos, G Davis, GE De Palma, M Dimberg, A Dings, RPM Djonov, V Dudley, AC Dufton, NP Fendt, S-M Ferrara, N Fruttiger, M Fukumura, D Ghesquière, B Gong, Y Griffin, RJ Harris, AL Hughes, CCW Hultgren, NW Iruela-Arispe, ML Irving, M Jain, RK Kalluri, R Kalucka, J Kerbel, RS Kitajewski, J Klaassen, I Kleinmann, HK Koolwijk, P Kuczynski, E Kwak, BR Marien, K Melero-Martin, JM Munn, LL Nicosia, RF Noel, A Nurro, J Olsson, A-K Petrova, TV Pietras, K Pili, R Pollard, JW Post, MJ Quax, PHA Rabinovich, GA Raica, M Randi, AM Ribatti, D Ruegg, C Schlingemann, RO Schulte-Merker, S Smith, LEH Song, JW Stacker, SA Stalin, J Stratman, AN Van de Velde, M Van Hinsbergh, VWM Vermeulen, PB Waltenberger, J Weinstein, BM Xin, H Yetkin-Arik, B Yla-Herttuala, S Yoder, MC Griffioen, AW |
| Item Type: | Journal Article |
| Abstract: | The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference. |
| Issue Date: | 1-Aug-2018 |
| Date of Acceptance: | 6-Apr-2018 |
| URI: | http://hdl.handle.net/10044/1/60013 |
| DOI: | https://dx.doi.org/10.1007/s10456-018-9613-x |
| ISSN: | 0969-6970 |
| Publisher: | Springer Verlag |
| Start Page: | 425 |
| End Page: | 532 |
| Journal / Book Title: | Angiogenesis |
| Volume: | 21 |
| Issue: | 3 |
| Copyright Statement: | © 2018 The Authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Sponsor/Funder: | British Heart Foundation British Heart Foundation British Heart Foundation British Heart Foundation British Heart Foundation Imperial College Healthcare Charity British Heart Foundation British Heart Foundation Rosetrees Trust British Heart Foundation |
| Funder's Grant Number: | PG/04/013/16655 PG/09/096/28114 RG/11/17/29256 PG/10/94/28651 RG/17/4/32662 AB55 PG/08/046/25077 FS/10/47/28393 A1132 PG/16/91/32515 |
| Keywords: | Science & Technology Life Sciences & Biomedicine Peripheral Vascular Disease Cardiovascular System & Cardiology Angiogenesis Aortic ring Endothelial cell migration Proliferation Microfluidic Zebrafish Chorioallantoic membrane (CAM) Vascular network Intussusceptive angiogenesis Retinal vasculature Corneal angiogenesis Hindlimb ischemia Myocardial angiogenesis Recombinant proteins Tip cells Plug assay Vessel co-option ENDOTHELIAL-GROWTH-FACTOR EMBRYO CHORIOALLANTOIC MEMBRANE VASCULAR-PERMEABILITY FACTOR PERIPHERAL ARTERIAL-DISEASE AORTIC RING MODEL VESSEL CO-OPTION PANCREATIC NEUROENDOCRINE TUMORS OXYGEN-INDUCED RETINOPATHY LIVING CAPILLARY NETWORKS ETS TRANSCRIPTION FACTORS Angiogenesis Aortic ring Chorioallantoic membrane (CAM) Corneal angiogenesis Endothelial cell migration Hindlimb ischemia Intussusceptive angiogenesis Microfluidic Myocardial angiogenesis Plug assay Proliferation Recombinant proteins Retinal vasculature Tip cells Vascular network Vessel co-option Zebrafish Angiogenesis Aortic ring Chorioallantoic membrane (CAM) Corneal angiogenesis Endothelial cell migration Hindlimb ischemia Intussusceptive angiogenesis Microfluidic Myocardial angiogenesis Plug assay Proliferation Recombinant proteins Retinal vasculature Tip cells Vascular network Vessel co-option Zebrafish Oncology & Carcinogenesis 1103 Clinical Sciences 1115 Pharmacology and Pharmaceutical Sciences |
| Publication Status: | Published |
| Online Publication Date: | 2018-05-15 |
| Appears in Collections: | National Heart and Lung Institute |