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Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts

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Title: Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts
Authors: Fuertes, E
Bracher, J
Flexeder, C
Markevych, I
Kluemper, C
Hoffmann, B
Kraemer, U
Von Berg, A
Bauer, C-P
Koletzko, S
Berdel, D
Heinrich, J
Schulz, H
Item Type: Journal Article
Abstract: Introduction The impact of outdoor air pollution exposure on long-term lung development and potential periods of increased lung susceptibility remain unknown. This study assessed associations between early-life and current residential exposure to air pollution and lung function at 15-years of age in two German birth cohorts. Methods Fifteen year-old participants living in an urban and rural area in Germany underwent spirometry before and after bronchodilation (N = 2266). Annual average (long-term) exposure to nitrogen dioxide (NO2), particles with aerodynamic diameters less than 2.5 μg/m3 (PM2.5) mass and less than 10 μg/m3 (PM10) mass, PM2.5 absorbance and ozone were estimated to each participant's birth-, 10- and 15-year home address using land-use regression and kriging (ozone only) modelling. Associations between lung function variables and long-term pollutant concentrations were assessed using linear regression models adjusted for host and environmental covariates and recent short-term air pollution exposures. Results Long-term air pollution concentrations assessed to the birth-, 10- and 15-year home addresses were not associated with lung function variables, before and after bronchodilation, in the complete or study area specific populations. However, several lung function variables were negatively associated with long-term NO2 concentrations among asthmatics. For example, NO2 estimated to the 15-year home address was associated with the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) and the mean flow rate between 25% and 75% of FVC (−3.5%, 95% confidence interval [−6.0, −1.0] and −297.4 ml/s [−592.6, −2.1] per 5.9 μg/m3 increase in NO2, respectively). Nearly all effect estimates for the associations between the short-term PM2.5 mass, PM10 mass and ozone concentrations and the lung function variables were negative in the complete population. Conclusions Early-life and current long-term air pollution exposures and lung function at the age of 15 years were not associated in the complete study population. Asthmatics may represent a vulnerable group.
Issue Date: 1-Oct-2015
Date of Acceptance: 12-Jul-2015
URI: http://hdl.handle.net/10044/1/60001
DOI: https://dx.doi.org/10.1016/j.ijheh.2015.07.003
ISSN: 1438-4639
Publisher: ELSEVIER GMBH, URBAN & FISCHER VERLAG
Start Page: 656
End Page: 665
Journal / Book Title: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Volume: 218
Issue: 7
Copyright Statement: © 2015 Elsevier GmbH. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Infectious Diseases
Air pollution
Asthma
Birth cohort
FEV1
FVC
Lung function
USE REGRESSION-MODELS
BIRTH COHORT
ESCAPE PROJECT
CHILDREN
AGE
ASSOCIATION
ASTHMA
NO2
SPIROMETRY
STABILITY
FEV(1)
Adolescent
Air Pollutants
Air Pollution
Cohort Studies
Environmental Exposure
Female
Forced Expiratory Volume
Germany
Humans
Linear Models
Lung
Male
Nitrogen Dioxide
Ozone
Particulate Matter
Rural Population
Spirometry
Urban Population
Vital Capacity
1117 Public Health And Health Services
Epidemiology
Toxicology
Publication Status: Published
Online Publication Date: 2015-07-17
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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