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Traffic-related air pollution and hyperactivity/inattention, dyslexia and dyscalculia in adolescents of the German GINIplus and LISAplus birth cohorts

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Title: Traffic-related air pollution and hyperactivity/inattention, dyslexia and dyscalculia in adolescents of the German GINIplus and LISAplus birth cohorts
Authors: Fuertes, E
Standl, M
Forns, J
Berdel, D
Garcia-Aymerich, J
Markevych, I
Schulte-Koerne, G
Sugiri, D
Schikowski, T
Tiesler, CMT
Heinrich, J
Item Type: Journal Article
Abstract: Background Few studies have examined the link between air pollution exposure and behavioural problems and learning disorders during late childhood and adolescence. Objectives To determine whether traffic-related air pollution exposure is associated with hyperactivity/inattention, dyslexia and dyscalculia up to age 15 years using the German GINIplus and LISAplus birth cohorts (recruitment 1995–1999). Methods Hyperactivity/inattention was assessed using the German parent-completed (10 years) and self-completed (15 years) Strengths and Difficulties Questionnaire. Responses were categorized into normal versus borderline/abnormal. Parent-reported dyslexia and dyscalculia (yes/no) at age 10 and 15 years were defined using parent-completed questionnaires. Individual-level annual average estimates of nitrogen dioxide (NO2), particulate matter (PM)10 mass, PM2.5 mass and PM2.5 absorbance concentrations were assigned to each participant's birth, 10 year and 15 year home address. Longitudinal associations between the air pollutants and the neurodevelopmental outcomes were assessed using generalized estimation equations, separately for both study areas, and combined in a random-effects meta-analysis. Odds ratios and 95% confidence intervals are given per interquartile range increase in pollutant concentration. Results The prevalence of abnormal/borderline hyperactivity/inattention scores and parental-reported dyslexia and dyscalculia at 15 years of age was 12.9%, 10.5% and 3.4%, respectively, in the combined population (N = 4745). In the meta- analysis, hyperactivity/inattention was associated with PM2.5 mass estimated to the 10 and 15 year addresses (1.12 [1.01, 1.23] and 1.11 [1.01, 1.22]) and PM2.5 absorbance estimated to the 10 and 15 year addresses (1.14 [1.05, 1.25] and 1.13 [1.04, 1.23], respectively). Conclusions We report associations suggesting a potential link between air pollution exposure and hyperactivity/inattention scores, although these findings require replication.
Issue Date: 1-Dec-2016
Date of Acceptance: 17-Oct-2016
URI: http://hdl.handle.net/10044/1/59997
DOI: https://dx.doi.org/10.1016/j.envint.2016.10.017
ISSN: 0160-4120
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Start Page: 85
End Page: 92
Journal / Book Title: ENVIRONMENT INTERNATIONAL
Volume: 97
Copyright Statement: © 2016 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Environmental Sciences & Ecology
Adolescents
Air pollution
Hyperactivity
Inattention
Neurodevelopment
USE REGRESSION-MODELS
ESCAPE PROJECT
DIFFICULTIES QUESTIONNAIRE
BEHAVIORAL-PROBLEMS
PM2.5 ABSORBENCY
NORMATIVE DATA
LUNG-FUNCTION
EXPOSURE
AREAS
STRENGTHS
Adolescent
Air Pollutants
Attention Deficit Disorder with Hyperactivity
Child
Dyscalculia
Dyslexia
Female
Germany
Humans
Male
Motor Vehicles
Nervous System Diseases
Nitrogen Dioxide
Particulate Matter
Vehicle Emissions
MD Multidisciplinary
Publication Status: Published
Online Publication Date: 2016-10-27
Appears in Collections:National Heart and Lung Institute