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Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Zamora-Ros_polyphenols and CRC_EJEP-D-17-01056_R1_accepted.pdf | Accepted version | 718.88 kB | Adobe PDF | View/Open |
Title: | Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort |
Authors: | Zamora-Ros, R Cayssials, V Jenab, M Rothwell, JA Fedirko, V Aleksandrova, K Tjønneland, A Kyrø, C Overvad, K Boutron-Ruault, M-C Carbonnel, F Mahamat-Saleh, Y Kaaks, R Kühn, T Boeing, H Trichopoulou, A Valanou, E Vasilopoulou, E Masala, G Pala, V Panico, S Tumino, R Ricceri, F Weiderpass, E Lukic, M Sandanger, TM Lasheras, C Agudo, A Sánchez, M-J Amiano, P Navarro, C Ardanaz, E Sonestedt, E Ohlsson, B Nilsson, LM Rutegård, M Bueno-de-Mesquita, B Peeters, PH Khaw, K-T Wareham, NJ Bradbury, K Freisling, H Romieu, I Cross, AJ Vineis, P Scalbert, A |
Item Type: | Journal Article |
Abstract: | Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women. |
Issue Date: | 1-Nov-2018 |
Date of Acceptance: | 4-May-2018 |
URI: | http://hdl.handle.net/10044/1/59840 |
DOI: | https://dx.doi.org/10.1007/s10654-018-0408-6 |
ISSN: | 0393-2990 |
Publisher: | Springer Verlag |
Start Page: | 1063 |
End Page: | 1075 |
Journal / Book Title: | European Journal of Epidemiology |
Volume: | 33 |
Issue: | 11 |
Copyright Statement: | © Springer Science+Business Media B.V., part of Springer Nature 2018. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs10654-018-0408-6 |
Keywords: | Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Polyphenols Intake Diet Colorectal cancer Prospective cohort EPIC COFFEE CONSUMPTION FLAVONOID INTAKE GUT MICROBIOTA TEA METAANALYSIS ASSOCIATION COUNTRIES EPIDEMIOLOGY METABOLOME BIOMARKERS Colorectal cancer Diet EPIC Intake Polyphenols Prospective cohort Adult Aged Coffee Cohort Studies Colorectal Neoplasms Europe Female Follow-Up Studies Humans Male Middle Aged Nutrition Assessment Polyphenols Prospective Studies Surveys and Questionnaires Tea Humans Colorectal Neoplasms Nutrition Assessment Cohort Studies Follow-Up Studies Prospective Studies Coffee Tea Adult Aged Middle Aged Europe Female Male Polyphenols Surveys and Questionnaires Colorectal cancer Diet EPIC Intake Polyphenols Prospective cohort 1117 Public Health and Health Services Epidemiology |
Publication Status: | Published |
Conference Place: | Netherlands |
Online Publication Date: | 2018-05-15 |
Appears in Collections: | School of Public Health |