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Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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Title: Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Authors: Zamora-Ros, R
Cayssials, V
Jenab, M
Rothwell, JA
Fedirko, V
Aleksandrova, K
Tjønneland, A
Kyrø, C
Overvad, K
Boutron-Ruault, M-C
Carbonnel, F
Mahamat-Saleh, Y
Kaaks, R
Kühn, T
Boeing, H
Trichopoulou, A
Valanou, E
Vasilopoulou, E
Masala, G
Pala, V
Panico, S
Tumino, R
Ricceri, F
Weiderpass, E
Lukic, M
Sandanger, TM
Lasheras, C
Agudo, A
Sánchez, M-J
Amiano, P
Navarro, C
Ardanaz, E
Sonestedt, E
Ohlsson, B
Nilsson, LM
Rutegård, M
Bueno-de-Mesquita, B
Peeters, PH
Khaw, K-T
Wareham, NJ
Bradbury, K
Freisling, H
Romieu, I
Cross, AJ
Vineis, P
Scalbert, A
Item Type: Journal Article
Abstract: Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
Issue Date: 1-Nov-2018
Date of Acceptance: 4-May-2018
URI: http://hdl.handle.net/10044/1/59840
DOI: https://dx.doi.org/10.1007/s10654-018-0408-6
ISSN: 0393-2990
Publisher: Springer Verlag
Start Page: 1063
End Page: 1075
Journal / Book Title: European Journal of Epidemiology
Volume: 33
Issue: 11
Copyright Statement: © Springer Science+Business Media B.V., part of Springer Nature 2018. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs10654-018-0408-6
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Polyphenols
Intake
Diet
Colorectal cancer
Prospective cohort
EPIC
COFFEE CONSUMPTION
FLAVONOID INTAKE
GUT MICROBIOTA
TEA
METAANALYSIS
ASSOCIATION
COUNTRIES
EPIDEMIOLOGY
METABOLOME
BIOMARKERS
Colorectal cancer
Diet
EPIC
Intake
Polyphenols
Prospective cohort
Adult
Aged
Coffee
Cohort Studies
Colorectal Neoplasms
Europe
Female
Follow-Up Studies
Humans
Male
Middle Aged
Nutrition Assessment
Polyphenols
Prospective Studies
Surveys and Questionnaires
Tea
Humans
Colorectal Neoplasms
Nutrition Assessment
Cohort Studies
Follow-Up Studies
Prospective Studies
Coffee
Tea
Adult
Aged
Middle Aged
Europe
Female
Male
Polyphenols
Surveys and Questionnaires
Colorectal cancer
Diet
EPIC
Intake
Polyphenols
Prospective cohort
1117 Public Health and Health Services
Epidemiology
Publication Status: Published
Conference Place: Netherlands
Online Publication Date: 2018-05-15
Appears in Collections:School of Public Health