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A CMOS-based Lab-on-Chip Array for the Combined Magnetic Stimulation and Opto-Chemical Sensing of Neural Tissue

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Title: A CMOS-based Lab-on-Chip Array for the Combined Magnetic Stimulation and Opto-Chemical Sensing of Neural Tissue
Authors: Constandinou, TG
Georgiou, P
Prodromakis, T
Toumazou, C
Item Type: Conference Paper
Abstract: This paper presents a novel CMOS-based lab-on-chip platform for non-contact magnetic stimulation and recording of neural tissue. The proposed system is the first of its kind to integrate magnetic-stimulation and opto-chemical sensing in a single pixel, tesselated to form an 8 × 8 array. Fabricated in a commercially-available 0.35 ¿m CMOS technology, the system can be intrinsically used for both optical imaging and pH sensing and includes mechanisms for calibrating out sensor variation and mismatch. In addition to sensory acquisition via an integrated 10-bit ADC, a 64-instruction spatiotemporal pattern generator has been embedded within the array for driving the microscale magnetic neural stimulation. In this application the ISFET-based sensors are used to capacitively-couple neuronal charge in close proximity to the floating gate. Optical imaging hardware has also been embedded to provide topographic detail of the neural tissue.
Content Version: Published version
Issue Date: 31-Dec-2010
URI: http://hdl.handle.net/10044/1/5969
Publisher Link: http://dx.doi.org/10.1109/CNNA.2010.5430288
DOI: 10.1109/CNNA.2010.5430288
ISBN: 978-1-4244-6679-5
Publisher: IEEE
Presented At: 2010 12th International Workshop on Cellular Nanoscale Networks and their Applications (CNNA)
Start Page: 1
End Page: 6
Copyright Statement: © 2010 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Place of Publication: Berkeley, CA
Conference Location: San Francisco, USA
Appears in Collections:Circuits and Systems