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The cooperative functions of the EBNA3 Proteins are central to EBV persistence and latency

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Title: The cooperative functions of the EBNA3 Proteins are central to EBV persistence and latency
Authors: Styles, CT
Paschos, K
White, R
Farrell, PJ
Item Type: Journal Article
Abstract: The Epstein–Barr nuclear antigen 3 (EBNA3) family of proteins, comprising EBNA3A, EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long latency of Epstein–Barr virus (EBV) in the worldwide human population. EBNA3-mediated transcriptional reprogramming of numerous host cell genes promotes in vitro B cell transformation and EBV persistence in vivo. Despite structural and sequence similarities, and evidence of substantial cooperative activity between the EBNA3 proteins, they perform quite different, often opposing functions. Both EBNA3A and EBNA3C are involved in the repression of important tumour suppressive pathways and are considered oncogenic. In contrast, EBNA3B exhibits tumour suppressive functions. This review focuses on how the EBNA3 proteins achieve the delicate balance required to support EBV persistence and latency, with emphasis on the contribution of the Allday laboratory to the field of EBNA3 biology.
Issue Date: 17-Mar-2018
Date of Acceptance: 7-Mar-2018
URI: http://hdl.handle.net/10044/1/58388
DOI: https://dx.doi.org/10.3390/pathogens7010031
ISSN: 2076-0817
Publisher: MDPI AG
Journal / Book Title: Pathogens
Volume: 31
Issue: 1
Copyright Statement: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 099273/Z/12/Z
Keywords: CDKI regulation
EBNA3 proteins
Epstein–Barr virus
epigenetic regulation
viral oncogenes
viral tumour suppressor
Publication Status: Published
Article Number: ARTN 31
Appears in Collections:Department of Medicine (up to 2019)