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The interplay of leukemia cells and the bone marrow microenvironment

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Title: The interplay of leukemia cells and the bone marrow microenvironment
Authors: Duarte, D
Hawkins, ED
Lo Celso, C
Item Type: Journal Article
Abstract: The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussions on the growth of leukemic cells are poorly understood. Recent development of novel imaging technology and preclinical disease models have advanced our comprehension of leukemia-microenvironment crosstalk and have potential implications for development of novel treatment options.
Issue Date: 5-Apr-2018
Date of Acceptance: 9-Feb-2018
URI: http://hdl.handle.net/10044/1/57841
DOI: https://dx.doi.org/10.1182/blood-2017-12-784132
ISSN: 1528-0020
Publisher: American Society of Hematology
Start Page: 1507
End Page: 1511
Journal / Book Title: Blood
Volume: 131
Issue: 14
Copyright Statement: © 2018 American Society of Hematology
Sponsor/Funder: Kay Kendall Leukemia Fund
Human Frontier Science Program
Bloodwise
Commission of the European Communities
European Hematology Association
Biotechnology and Biological Sciences Research Council (BBSRC)
Bloodwise
Funder's Grant Number: KKL460
rgp0051/2011
12033
337066
n/a
BB/L023776/1
15040
Keywords: 1102 Cardiovascular Medicine And Haematology
1103 Clinical Sciences
1114 Paediatrics And Reproductive Medicine
Immunology
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-02-27
Appears in Collections:Faculty of Natural Sciences