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Gene expression during the activation of human B cells

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Title: Gene expression during the activation of human B cells
Authors: Zhang, Y
Item Type: Chapter
Abstract: Human B lymphocytes not only play the critical role in the humoral immunity to generate antibodies, but also equally important to cellular immunity as B lymphocytes can present antigens to T lymphocytes and can release a range of potential immune-regulating cytokines after stimulations. Human immunoglobulin class switch recombination (CSR) in activated B cells is an essential process in the humoral immunity and the process is complicated and tightly controlled by many regulators. The recent genomic and genetic approaches in CSR identified novel genes that were actively involved in the process. Understanding the roles of the novel genes in CSR will bring new insights into the mechanisms of the process and new potential therapeutic targets for immunoglobulin-related disorders such as allergic asthma and autoimmune diseases.
Editors: Uchiumi, F
Issue Date: 21-Feb-2018
URI: http://hdl.handle.net/10044/1/57382
DOI: https://dx.doi.org/10.5772/intechopen.71863
ISBN: 978-953-51-3856-3
Publisher: InTechOpen
Journal / Book Title: Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects
Format Info.: 15
Volume: 1
Copyright Statement: © 2018 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: B cells; immunoglobulin class switch recombination; gene expression; regulation
Notes: n/a
Edition: 1
Place of Publication: Rijeka, Croatia
Publication Status: Published
Article Number: 9
Appears in Collections:National Heart and Lung Institute