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A high-performance application specific integrated circuit for electrical and neurochemical traumatic brain injury monitoring

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Title: A high-performance application specific integrated circuit for electrical and neurochemical traumatic brain injury monitoring
Authors: Pagkalos, I
Rogers, M
Boutelle, MG
Drakakis, EM
Item Type: Journal Article
Abstract: This paper presents the first application specific integrated chip (ASIC) for the monitoring of patients who have suffered a Traumatic Brain Injury (TBI). By monitoring the neuralphysiological (ECoG) and neurochemical (glucose, lactate and potassium) signals of the injured human brain tissue, it is possible to detect spreading depolarisations, which have been shown to be associated with poor TBI patient outcome. This paper describes the testing of a new 7.5mm2 ASIC fabricated in the commercially available AMS 0.35μm CMOS technology. The ASIC has been designed to meet the demands of processing the injured brain tissue's ECoG signals, recorded by means of depth or brain surface electrodes, and neurochemical signals, recorded using microdialysis coupled to microfluidics-based electrochemical biosensors. The potentiostats use switched-capacitor charge integration to record currents with 100fA resolution, and allow automatic gain changing to track the falling sensitivity of a biosensor. This work supports the idea of a "behind the ear" wireless microplatform modality, which could enable the monitoring of currently non-monitored mobile TBI patients for the onset of secondary brain injury.
Issue Date: 22-May-2018
Date of Acceptance: 26-Jan-2018
URI: http://hdl.handle.net/10044/1/57007
DOI: 10.1002/cphc.201701119
ISSN: 1439-4235
Publisher: Wiley
Start Page: 1215
End Page: 1225
Journal / Book Title: ChemPhysChem: a European journal of chemical physics and physical chemistry
Volume: 19
Issue: 10
Copyright Statement: © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Funder's Grant Number: NA
094912/Z/10/Z
Keywords: Application Specific Integrated Chip for Neurochemical Monitoring
Traumatic Brain Injury
Science & Technology
Physical Sciences
Chemistry, Physical
Physics, Atomic, Molecular & Chemical
Chemistry
Physics
CONTINUOUS ONLINE MICRODIALYSIS
HUMAN CEREBRAL-CORTEX
SPREADING DEPOLARIZATIONS
DEPRESSION
GLUCOSE
LACTATE
Brain Injuries, Traumatic
Electricity
Humans
Neurophysiological Monitoring
Humans
Electricity
Neurophysiological Monitoring
Brain Injuries, Traumatic
0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics
0306 Physical Chemistry (incl. Structural)
0307 Theoretical and Computational Chemistry
Chemical Physics
Publication Status: Published
Conference Place: Germany
Online Publication Date: 2018-01-31
Appears in Collections:Bioengineering
Faculty of Engineering