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Uptake and impact of vaccinating school age children against influenza during a season with circulation of drifted influenza A and B strains, England, 2014/15

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Title: Uptake and impact of vaccinating school age children against influenza during a season with circulation of drifted influenza A and B strains, England, 2014/15
Authors: Pebody, RG
Green, HK
Andrews, N
Boddington, NL
Zhao, H
Yonova, I
Ellis, J
Steinberger, S
Donati, M
Elliot, AJ
Hughes, HE
Pathirannehelage, S
Mullett, D
Smith, GE
De Lusignan, S
Zambon, M
Item Type: Journal Article
Abstract: The 2014/15 influenza season was the second season of roll-out of a live attenuated influenza vaccine (LAIV) programme for healthy children in England. During this season, besides offering LAIV to all two to four year olds, several areas piloted vaccination of primary (4–11 years) and secondary (11–13 years) age children. Influenza A(H3N2) circulated, with strains genetically and antigenically distinct from the 2014/15 A(H3N2) vaccine strain, followed by a drifted B strain. We assessed the overall and indirect impact of vaccinating school age children, comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot to non-pilot areas. Uptake levels were 56.8% and 49.8% in primary and secondary school pilot areas respectively. In primary school age pilot areas, cumulative primary care influenza-like consultation, emergency department respiratory attendance, respiratory swab positivity, hospitalisation and excess respiratory mortality were consistently lower in targeted and non-targeted age groups, though less for adults and more severe end-points, compared with non-pilot areas. There was no significant reduction for excess all-cause mortality. Little impact was seen in secondary school age pilot only areas compared with non-pilot areas. Vaccination of healthy primary school age children resulted in population-level impact despite circulation of drifted A and B influenza strains.
Issue Date: 1-Oct-2015
Date of Acceptance: 9-Sep-2015
URI: http://hdl.handle.net/10044/1/56855
DOI: https://dx.doi.org/10.2807/1560-7917.ES.2015.20.39.30029
ISSN: 1560-7917
Publisher: European Centre for Disease Prevention and Control
Start Page: 37
End Page: 47
Journal / Book Title: Eurosurveillance
Volume: 20
Issue: 39
Copyright Statement: This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Child, Preschool
Immunization Programs
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza Vaccines
Influenza, Human
Pilot Projects
Vaccines, Attenuated
Publication Status: Published
Article Number: 30029
Appears in Collections:National Heart and Lung Institute