Altmetric

Neuronal gain modulability is determined by dendritic morphology: a computational optogenetic study

File Description SizeFormat 
journal.pcbi.1006027.pdfPublished version5.48 MBAdobe PDFView/Open
Title: Neuronal gain modulability is determined by dendritic morphology: a computational optogenetic study
Authors: Jarvis, S
Nikolic, K
Schultz, SR
Item Type: Journal Article
Abstract: The mechanisms by which the gain of the neuronal input-output function may be modulated have been the subject of much investigation. However, little is known of the role of dendrites in neuronal gain control. New optogenetic experimental paradigms based on spatial profiles or patterns of light stimulation offer the prospect of elucidating many aspects of single cell function, including the role of dendrites in gain control. We thus developed a model to investigate how competing excitatory and inhibitory input within the dendritic arbor alters neuronal gain, incorporating kinetic models of opsins into our modeling to ensure it is experimentally testable. To investigate how different topologies of the neuronal dendritic tree affect the neuron’s input-output characteristics we generate branching geometries which replicate morphological features of most common neurons, but keep the number of branches and overall area of dendrites approximately constant. We found a relationship between a neuron’s gain modulability and its dendritic morphology, with neurons with bipolar dendrites with a moderate degree of branching being most receptive to control of the gain of their input-output relationship. The theory was then tested and confirmed on two examples of realistic neurons: 1) layer V pyramidal cells—confirming their role in neural circuits as a regulator of the gain in the circuit in addition to acting as the primary excitatory neurons, and 2) stellate cells. In addition to providing testable predictions and a novel application of dual-opsins, our model suggests that innervation of all dendritic subdomains is required for full gain modulation, revealing the importance of dendritic targeting in the generation of neuronal gain control and the functions that it subserves. Finally, our study also demonstrates that neurophysiological investigations which use direct current injection into the soma and bypass the dendrites may miss some important neuronal functions, such as gain modulation.
Issue Date: 9-Mar-2018
Date of Acceptance: 7-Feb-2018
URI: http://hdl.handle.net/10044/1/56828
DOI: https://dx.doi.org/10.1371/journal.pcbi.1006027
ISSN: 1553-734X
Publisher: Public Library of Science (PLoS)
Journal / Book Title: PLoS Computational Biology
Volume: 14
Issue: 3
Copyright Statement: © 2018 Jarvis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricte d use, distribu tion, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Commission of the European Communities
Wellcome Trust
National Institutes of Health
Funder's Grant Number: BB/L018268/1
PIEF-GA-2013-628086
105603/Z/14/Z
UPMC: C15/0244
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Mathematical & Computational Biology
Biochemistry & Molecular Biology
NEOCORTICAL PYRAMIDAL NEURONS
MEDIAL ENTORHINAL CORTEX
SHUNTING INHIBITION
SYNAPTIC INTEGRATION
CELLULAR MECHANISMS
FIRING RATE
IN-VIVO
CHANNELRHODOPSIN-2
MODULATION
EXCITATION
06 Biological Sciences
08 Information And Computing Sciences
01 Mathematical Sciences
Bioinformatics
Publication Status: Published
Article Number: e1006027
Appears in Collections:Faculty of Engineering
Bioengineering
Electrical and Electronic Engineering



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons