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Maintaining quality of candidate strains of transgenic mosquitoes for studies in containment facilities in disease endemic countries

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Title: Maintaining quality of candidate strains of transgenic mosquitoes for studies in containment facilities in disease endemic countries
Authors: Mumford, JD
Leach, AW
Benedict, MQ
Facchinelli, L
Quinlan, MM
Item Type: Journal Article
Abstract: Transgenic mosquitoes are being developed as novel components of area-wide approaches to vector-borne disease control. Best practice is to develop these in phases, beginning with laboratory studies, before moving to field testing and inclusion in control programs, to ensure safety and prevent costly field testing of unsuitable strains. The process of identifying and developing good candidate strains requires maintenance of transgenic colonies over many generations in containment facilities. By working in disease endemic countries with target vector populations, laboratory strains may be developed and selected for properties that will enhance intended control efficacy in the next phase, while avoiding traits that introduce unnecessary risks. Candidate strains aiming toward field use must consistently achieve established performance criteria, throughout the process of scaling up from small study colonies to production of sufficient numbers for field testing and possible open release. Maintenance of a consistent quality can be demonstrated by a set of insect quality and insectary operating indicators, measured over time at predetermined intervals. These indicators: inform comparability of studies using various candidate strains at different times and locations; provide evidence of conformity relevant to compliance with terms of approval for regulated use; and can be used to validate some assumptions related to risk assessments covering the contained phase and for release into the environment.
Issue Date: 1-Jan-2018
Date of Acceptance: 1-Jan-2018
URI: http://hdl.handle.net/10044/1/56301
DOI: https://dx.doi.org/10.1089/vbz.2017.2208
ISSN: 1530-3667
Publisher: Mary Ann Liebert
Start Page: 31
End Page: 38
Journal / Book Title: Vector-Borne and Zoonotic Diseases
Volume: 18
Issue: 1
Copyright Statement: © John D. Mumford et al. 2018 Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: containment
insectary
mosquitoes
quality assurance
transgenic
1117 Public Health And Health Services
Tropical Medicine
Publication Status: Published
Conference Place: United States
Open Access location: http://online.liebertpub.com/doi/10.1089/vbz.2017.2208
Appears in Collections:Centre for Environmental Policy