49
IRUS TotalDownloads
Altmetric
An epigenetic switch: from senescent melanocytes to malignant melanoma (and back)
| File | Description | Size | Format | |
|---|---|---|---|---|
 Wagnerpreview3.pdf | Accepted version | 725.72 kB | Adobe PDF | View/Open |
| Title: | An epigenetic switch: from senescent melanocytes to malignant melanoma (and back) |
| Authors: | Wagner, V Gil, J |
| Item Type: | Journal Article |
| Abstract: | Oncogene-induced senescence is an important barrier during melanomagenesis. In this issue of Cancer Cell, Yu et al. show how elevated expression of structurally unrelated H3K9 demethylases disables senescence and constitutes a liability that can be exploited to restore senescence in melanoma by pharmacological inhibition of these epigenetic regulators. |
| Issue Date: | 12-Feb-2018 |
| Date of Acceptance: | 22-Jan-2018 |
| URI: | http://hdl.handle.net/10044/1/56298 |
| DOI: | https://dx.doi.org/10.1016/j.ccell.2018.01.013 |
| ISSN: | 1535-6108 |
| Publisher: | Elsevier (Cell Press) |
| Start Page: | 162 |
| End Page: | 163 |
| Journal / Book Title: | Cancer Cell |
| Volume: | 33 |
| Issue: | 2 |
| Copyright Statement: | © 2018 Elsevier Inc. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ 2019-02-12 |
| Keywords: | 1112 Oncology And Carcinogenesis 1109 Neurosciences Oncology & Carcinogenesis |
| Publication Status: | Published |
| Appears in Collections: | Institute of Clinical Sciences |