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Closed-loop control for precision antimicrobial delivery: an In silico proof-of-concept
| File | Description | Size | Format | |
|---|---|---|---|---|
 08239859.pdf | Accepted version | 1.11 MB | Adobe PDF | View/Open |
| Title: | Closed-loop control for precision antimicrobial delivery: an In silico proof-of-concept |
| Authors: | Herrero, P Rawson, TM Philip, A Moore, LSP Holmes, AH Georgiou, P |
| Item Type: | Journal Article |
| Abstract: | IEEE Objective: Inappropriate dosing of patients with antibiotics is a driver of antimicrobial resistance, toxicity, and poor outcomes of therapy. In this paper, we investigate, in silico, the hypothesis that the use of a closed-loop control system could improve the attainment of pharmacokinetic-pharmacodynamic targets for antimicrobial therapy, where wide variations in target attainment have been reported. This includes patients in critical care, patients with renal disease and patients with obesity. |
| Issue Date: | 1-Oct-2018 |
| Date of Acceptance: | 25-Dec-2017 |
| URI: | http://hdl.handle.net/10044/1/56020 |
| DOI: | 10.1109/TBME.2017.2787423 |
| ISSN: | 0018-9294 |
| Publisher: | Institute of Electrical and Electronics Engineers |
| Start Page: | 2231 |
| End Page: | 2236 |
| Journal / Book Title: | IEEE Transactions on Biomedical Engineering |
| Volume: | 65 |
| Issue: | 10 |
| Copyright Statement: | © 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
| Sponsor/Funder: | National Institute for Health Research National Institute for Health Research National Institute for Health Research National Institute for Health Research |
| Funder's Grant Number: | HPRU-2012-10047 HPRU-2012-10047 II-LA-0214-20008 II-LA-0214-20008 |
| Keywords: | Science & Technology Technology Engineering, Biomedical Engineering Antimicrobial resistance closed-loop control PID control precision medicine TROUGH CONCENTRATIONS VANCOMYCIN INFECTIONS INFUSION 0903 Biomedical Engineering 0906 Electrical And Electronic Engineering 0801 Artificial Intelligence And Image Processing Biomedical Engineering |
| Publication Status: | Published |
| Online Publication Date: | 2017-12-25 |
| Appears in Collections: | Electrical and Electronic Engineering Department of Medicine (up to 2019) Faculty of Engineering |