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The mitochondria and the regulation of cell fitness during early mammalian development

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Title: The mitochondria and the regulation of cell fitness during early mammalian development
Authors: Lima, A
Burgstaller, J
Sanchez Nieto, JM
Rodriguez, T
Item Type: Journal Article
Abstract: From fertilization until the onset of gastrulation the early mammalian embryo undergoes a dramatic series of changes that converts a single fertilized cell into a remarkably complex organism. Much attention has been given to the molecular changes occurring during this process, but here we will review what is known about the changes affecting the mitochondria and how they impact on the energy metabolism and apoptotic response of the embryo. We will also focus on understanding what quality control mechanisms ensure optimal mitochondrial activity in the embryo, and in this way provide an overview of the importance of the mitochondria in determining cell fitness during early mammalian development.
Issue Date: 12-Dec-2017
Date of Acceptance: 23-Oct-2017
URI: http://hdl.handle.net/10044/1/55861
DOI: https://dx.doi.org/10.1016/bs.ctdb.2017.10.012
ISSN: 0070-2153
Publisher: Elsevier
Start Page: 339
End Page: 363
Journal / Book Title: Current Topics in Developmental Biology
Volume: 128
Copyright Statement: © 2018 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: British Heart Foundation
British Heart Foundation
Medical Research Council (MRC)
Funder's Grant Number: RE/13/4/30184
FS/14/62/31288
MR/P018467/1
Keywords: Apoptosis
Cell fitness
Energy metabolism
Mitochondria
Oxidative phosphorylation
Postimplantation embryo
Preimplantation embryo
mtDNA
0601 Biochemistry And Cell Biology
1114 Paediatrics And Reproductive Medicine
Developmental Biology
Publication Status: Published
Appears in Collections:National Heart and Lung Institute