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The human female urogenital microbiome: complexity in normality

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Title: The human female urogenital microbiome: complexity in normality
Authors: MacIntyre, DA
Sykes, L
Bennett, P
Item Type: Journal Article
Abstract: Microbial communities of the urogenital tract have long been recognised to play an important role in disease states. A revolution in methodological approaches is permitting the assessment of complex urogenital tract microbiota–host interactions and the metabolic and protein milieu of the mucosal interface. There is now great potential for significant advances in biomarker discovery and disease risk stratification, and for the elucidation of mechanisms underpinning the microbial community dynamics involved in urogenital tract pathology. Microbiota–host interactions in the female genital tract have a particular significance, because unlike in the male, there is direct communication between the external genitalia, the uterus and the peritoneal cavity. This review examines the microbial community composition at differing sites of the female urogenital tract and its relationship with health and disease. Key factors involved in the modulation of vaginal microbiome stability and structure, such as endocrine, immune and inflammatory pathways, are considered in the context of a woman's life cycle and disease pathogenesis.
Issue Date: 30-Nov-2017
Date of Acceptance: 29-Sep-2017
URI: http://hdl.handle.net/10044/1/55830
DOI: https://dx.doi.org/10.1042/ETLS20170042
ISSN: 2397-8554
Publisher: Portland Press
Start Page: 363
End Page: 372
Journal / Book Title: Emerging Topics in Life Sciences
Volume: 1
Issue: 4
Copyright Statement: © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Genesis Research Trust
Seattle ChildrensHospital Research Foundation
Funder's Grant Number: MR/L009226/1
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer