Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Demenais, F; Margaritte-Jeannin, P; Barnes, KC; Cookson, WOC; Altmüller, J; Ang, W; Barr, RG; Beaty, TH; Becker, AB; Beilby, J; Bisgaard, H; Bjornsdottir, US; Bleecker, E; Bønnelykke, K; Boomsma, DI; Bouzigon, E; Brightling, CE; Brossard, M; Brusselle, GG; Burchard, E; Burkart, KM; Bush, A; Chan-Yeung, M; Chung, KF; Couto Alves, A; Curtin, JA; Custovic, A; Daley, D; De Jongste, JC; Del-Rio-Navarro, BE; Donohue, KM; Duijts, L; Eng, C; Eriksson, JG; Farrall, M; Fedorova, Y; Feenstra, B; Ferreira, MA; Australian Asthma Genetics Consortium (AAGC) collaborators; Freidin, MB; Gajdos, Z; Gauderman, J; Gehring, U; Geller, F; Genuneit, J; Gharib, SA; Gilliland, F; Granell, R; Graves, PE; Gudbjartsson, DF; Haahtela, T; Heckbert, SR; Heederik, D; Heinrich, J; Heliövaara, M; Henderson, J; Himes, BE; Hirose, H; Hirschhorn, JN; Hofman, A; Holt, P; Hottenga, J; Hudson, TJ; Hui, J; Imboden, M; Ivanov, V; Jaddoe, VWV; James, A; Janson, C; Jarvelin, M-R; Jarvis, D; Jones, G; Jonsdottir, I; Jousilahti, P; Kabesch, M; Kähönen, M; Kantor, DB; Karunas, AS; Khusnutdinova, E; Koppelman, GH; Kozyrskyj, AL; Kreiner, E; Kubo, M; Kumar, R; Kumar, A; Kuokkanen, M; Lahousse, L; Laitinen, T; Laprise, C; Lathrop, M; Lau, S; Lee, Y-A; Lehtimäki, T; Letort, S; Levin, AM; Li, G; Liang, L; Loehr, LR; London, SJ; Loth, DW; Manichaikul, A; Marenholz, I; Martinez, FJ; Matheson, MC; Mathias, RA; Matsumoto, K; Mbarek, H; McArdle, WL; Melbye, M; Melén, E; Meyers, D; Michel, S; Mohamdi, H; Musk, AW; Myers, RA; Nieuwenhuis, MAE; Noguchi, E; O'Connor, GT; Ogorodova, LM; Palmer, CD; Palotie, A; Park, JE; Pennell, CE; Pershagen, G; Polonikov, A; Postma, DS; Probst-Hensch, N; Puzyrev, VP; Raby, BA; Raitakari, OT; Ramasamy, A; Rich, SS; Robertson, CF; Romieu, I; Salam, MT; Salomaa, V; Schlünssen, V; Scott, R; Selivanova, PA; Sigsgaard, T; Simpson, A; Siroux, V; Smith, LJ; Solodilova, M; Standl, M; Stefansson, K; Strachan, DP; Stricker, BH; Takahashi, A; Thompson, PJ; Thorleifsson, G; Thorsteinsdottir, U; Tiesler, CMT; Torgerson, DG; Tsunoda, T; Uitterlinden, AG; Van der Valk, RJP; Vaysse, A; Vedantam, S; Von Berg, A; Von Mutius, E; Vonk, JM; Waage, J; Wareham, NJ; Weiss, ST; White, WB; Wickman, M; Widén, E; Willemsen, G; Williams, LK; Wouters, IM; Yang, JJ; Zhao, JH; Moffatt, MF; Ober, C; Nicolae, DL

144

IRUS Total
Downloads

Altmetric

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

File	Description	Size	Format
46953_3_merged_1508962094.pdf	Accepted version	23.04 MB	Adobe PDF	View/Open

Title:	Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Authors:	Demenais, F Margaritte-Jeannin, P Barnes, KC Cookson, WOC Altmüller, J Ang, W Barr, RG Beaty, TH Becker, AB Beilby, J Bisgaard, H Bjornsdottir, US Bleecker, E Bønnelykke, K Boomsma, DI Bouzigon, E Brightling, CE Brossard, M Brusselle, GG Burchard, E Burkart, KM Bush, A Chan-Yeung, M Chung, KF Couto Alves, A Curtin, JA Custovic, A Daley, D De Jongste, JC Del-Rio-Navarro, BE Donohue, KM Duijts, L Eng, C Eriksson, JG Farrall, M Fedorova, Y Feenstra, B Ferreira, MA Australian Asthma Genetics Consortium (AAGC) collaborators Freidin, MB Gajdos, Z Gauderman, J Gehring, U Geller, F Genuneit, J Gharib, SA Gilliland, F Granell, R Graves, PE Gudbjartsson, DF Haahtela, T Heckbert, SR Heederik, D Heinrich, J Heliövaara, M Henderson, J Himes, BE Hirose, H Hirschhorn, JN Hofman, A Holt, P Hottenga, J Hudson, TJ Hui, J Imboden, M Ivanov, V Jaddoe, VWV James, A Janson, C Jarvelin, M-R Jarvis, D Jones, G Jonsdottir, I Jousilahti, P Kabesch, M Kähönen, M Kantor, DB Karunas, AS Khusnutdinova, E Koppelman, GH Kozyrskyj, AL Kreiner, E Kubo, M Kumar, R Kumar, A Kuokkanen, M Lahousse, L Laitinen, T Laprise, C Lathrop, M Lau, S Lee, Y-A Lehtimäki, T Letort, S Levin, AM Li, G Liang, L Loehr, LR London, SJ Loth, DW Manichaikul, A Marenholz, I Martinez, FJ Matheson, MC Mathias, RA Matsumoto, K Mbarek, H McArdle, WL Melbye, M Melén, E Meyers, D Michel, S Mohamdi, H Musk, AW Myers, RA Nieuwenhuis, MAE Noguchi, E O'Connor, GT Ogorodova, LM Palmer, CD Palotie, A Park, JE Pennell, CE Pershagen, G Polonikov, A Postma, DS Probst-Hensch, N Puzyrev, VP Raby, BA Raitakari, OT Ramasamy, A Rich, SS Robertson, CF Romieu, I Salam, MT Salomaa, V Schlünssen, V Scott, R Selivanova, PA Sigsgaard, T Simpson, A Siroux, V Smith, LJ Solodilova, M Standl, M Stefansson, K Strachan, DP Stricker, BH Takahashi, A Thompson, PJ Thorleifsson, G Thorsteinsdottir, U Tiesler, CMT Torgerson, DG Tsunoda, T Uitterlinden, AG Van der Valk, RJP Vaysse, A Vedantam, S Von Berg, A Von Mutius, E Vonk, JM Waage, J Wareham, NJ Weiss, ST White, WB Wickman, M Widén, E Willemsen, G Williams, LK Wouters, IM Yang, JJ Zhao, JH Moffatt, MF Ober, C Nicolae, DL
Item Type:	Journal Article
Abstract:	We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Issue Date:	22-Dec-2017
Date of Acceptance:	8-Nov-2017
URI:	http://hdl.handle.net/10044/1/55618
DOI:	10.1038/s41588-017-0014-7
ISSN:	1061-4036
Publisher:	Nature Publishing Group
Start Page:	42
End Page:	53
Journal / Book Title:	Nature Genetics
Volume:	50
Issue:	1
Copyright Statement:	Copyright © 2017, Springer Nature
Sponsor/Funder:	Medical Research Council (MRC) National Institute for Health Research Wellcome Trust Medical Research Council (MRC)
Funder's Grant Number:	MR/K002449/1 NF-SI-0515-10016 096964/Z/11/Z MR/K002449/2
Keywords:	Science & Technology Life Sciences & Biomedicine Genetics & Heredity GENOME-WIDE ASSOCIATION AUTOIMMUNE-DISEASE HAY-FEVER VARIANTS METAANALYSIS EXPRESSION GENE POPULATIONS TWINS Alleles Asthma Enhancer Elements, Genetic Epigenesis, Genetic Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Histone Code Humans Leukocytes Phenotype Promoter Regions, Genetic Rhinitis, Allergic, Seasonal Risk Australian Asthma Genetics Consortium (AAGC) collaborators Leukocytes Humans Asthma Genetic Predisposition to Disease Risk Epigenesis, Genetic Histone Code Phenotype Alleles Rhinitis, Allergic, Seasonal Enhancer Elements, Genetic Promoter Regions, Genetic Genome-Wide Association Study Genetic Loci 06 Biological Sciences 11 Medical and Health Sciences Developmental Biology
Publication Status:	Published
Online Publication Date:	2017-12-22
Appears in Collections:	Department of Infectious Diseases National Heart and Lung Institute Faculty of Medicine School of Public Health