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Stresses and strains on the human fetal skeleton during development

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Title: Stresses and strains on the human fetal skeleton during development
Authors: Verbruggen, S
Kainz, B
Shelmerdine, S
Hajnal, J
Rutherford, M
Arthurs, O
Phillips, A
Nowlan, NC
Item Type: Journal Article
Abstract: Mechanical forces generated by fetal kicks and movements result in stimulation of the fetal skeleton in the form of stress and strain. This stimulation is known to be critical for prenatal musculoskeletal development; indeed, abnormal or absent movements have been implicated in multiple congenital disorders. However, the mechanical stress and strain experienced by the developing human skeleton in utero have never before been characterized. Here, we quantify the biomechanics of fetal movements during the second half of gestation by modelling fetal movements captured using novel cine-magnetic resonance imaging technology. By tracking these movements, quantifying fetal kick and muscle forces, and applying them to three-dimensional geometries of the fetal skeleton, we test the hypothesis that stress and strain change over ontogeny. We find that fetal kick force increases significantly from 20 to 30 weeks' gestation, before decreasing towards term. However, stress and strain in the fetal skeleton rises significantly over the latter half of gestation. This increasing trend with gestational age is important because changes in fetal movement patterns in late pregnancy have been linked to poor fetal outcomes and musculoskeletal malformations. This research represents the first quantification of kick force and mechanical stress and strain due to fetal movements in the human skeleton in utero, thus advancing our understanding of the biomechanical environment of the uterus. Further, by revealing a potential link between fetal biomechanics and skeletal malformations, our work will stimulate future research in tissue engineering and mechanobiology.
Issue Date: 24-Jan-2018
Date of Acceptance: 18-Dec-2017
URI: http://hdl.handle.net/10044/1/55601
DOI: https://dx.doi.org/10.1098/rsif.2017.0593
ISSN: 1742-5662
Publisher: Royal Society, The
Journal / Book Title: Journal of the Royal Society Interface
Volume: 15
Issue: 138
Copyright Statement: © 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Sponsor/Funder: Arthritis Research UK
Wellcome Trust/EPSRC
Wellcome Trust
Engineering & Physical Science Research Council (E
Funder's Grant Number: 20683
NS/A000025/1
RTJ5557761
RTJ5557761-1
Keywords: biomechanical stimuli
cine-MRI
finite element analysis
joint biomechanics
musculo-skeletal development
MD Multidisciplinary
General Science & Technology
Publication Status: Published online
Article Number: 20170593
Appears in Collections:Faculty of Engineering
Civil and Environmental Engineering
Bioengineering
Computing



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