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Sugar detection threshold after laparoscopic sleeve gastrectomy in adolescents

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Title: Sugar detection threshold after laparoscopic sleeve gastrectomy in adolescents
Authors: Abdeen, GN
Miras, AD
Alqhatani, AR
Le Roux, CW
Item Type: Journal Article
Abstract: INTRODUCTION: Obesity in young people is one of the most serious public health problems worldwide. Moreover, the mechanisms preventing obese adolescents from losing and maintaining weight loss have been elusive. Laparoscopic sleeve gastrectomy (LSG) is successful at achieving long-term weight loss in patients across all age groups, including children and adolescents. Anecdotal clinical observation as well as evidence in rodents suggests that LSG induces a shift in preference of sugary foods. However, it is not known whether this shift is due to a change in the threshold for gustatory detection of sucrose, or whether LSG induces behavioral change without affecting the gustatory threshold for sugar. AIMS: The objective of this study was to determine whether adolescents who undergo LSG experience a change in their threshold for detecting sweet taste. METHODS: We studied the sucrose detection threshold of 14 obese adolescents (age 15.3 ± 0.5 years, range 12-18) who underwent LSG 2 weeks before surgery and at 12 and 52 weeks after surgery. Matched non-surgical subjects were tested on two occasions 12 weeks apart to control for potential learning of the test that may have confounded the results. Seven sucrose concentrations were used and were tested in eight blocks with each block consisting of a random seven sucrose and seven water stimuli. The subjects were asked to report whether the sample contained water or not after they tasted 15 ml of the fluid for 10 s. RESULTS: The bodyweight of the LSG group decreased from 136.7 ± 5.4 to 109.6 ± 5.1 and 86.5 ± 4.0 kg after 12 and 52 weeks, respectively (p < 0.001). There was no significant difference after surgery in taste detection threshold of patients after LSG (p = 0.60), and no difference was observed comparing the taste detection threshold of the LSG group with the non-surgical controls (p = 0.38). CONCLUSION: LSG did not affect the taste detection threshold for sucrose, suggesting that the shift in preference for sugary foods may be due to factors other than fundamental changes in taste sensitivity.
Issue Date: 1-May-2018
Date of Acceptance: 1-Dec-2017
URI: http://hdl.handle.net/10044/1/55008
DOI: https://dx.doi.org/10.1007/s11695-017-2999-5
ISSN: 0960-8923
Publisher: Springer Verlag
Start Page: 1302
End Page: 1307
Journal / Book Title: Obesity Surgery
Volume: 28
Issue: 5
Copyright Statement: © Springer Science+Business Media, LLC 2017. The final publication is available at Springer via http://dx.doi.org/10.1007/s11695-017-2999-5
Sponsor/Funder: ONO Pharmaceuticals Co Ltd
Funder's Grant Number: N/A
Keywords: Adolescents
Sleeve gastrectomy
Sweets preference
Taste detection
1103 Clinical Sciences
1117 Public Health And Health Services
Surgery
Publication Status: Published
Online Publication Date: 2017-12-02
Appears in Collections:Department of Medicine (up to 2019)