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Whole grain cereals for the primary or secondary prevention of cardiovascular disease

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Title: Whole grain cereals for the primary or secondary prevention of cardiovascular disease
Authors: Kelly, SAM
Hartley, L
Loveman, E
Colquitt, JL
Jones, HM
Al-Khudairy, L
Clar, C
Germano, R
Lunn, HR
Frost, G
Rees, K
Item Type: Journal Article
Abstract: Background There is evidence from observational studies that whole grai ns can have a beneficial effect on risk for cardiovascular disease (C VD). Earlier versions of this review found mainly short-term inte rvention studies. There are now longer-term randomised contr olled trials (RCTs) available. This is an update and expansion of the origi nal review conducted in 2007. Objectives The aim of this systematic review was to assess the effect of wh ole grain foods or diets on total mortality, cardiovascular ev ents, and cardiovascular risk factors (blood lipids, blood pressure) in h ealthy people or people who have established cardiovascular d isease or related risk factors, using all eligible RCTs. Search methods We searched CENTRAL (Issue 8, 2016) in the Cochrane Library, MED LINE (1946 to 31 August 2016), Embase (1980 to week 35 2016), and CINAHL Plus (1937 to 31 August 2016) on 31 August 2016 . We also searched ClinicalTrials.gov on 5 July 2017 and the World Health Organization International Clinical Trials Re gistry Platform (WHO ICTRP) on 6 July 2017. We checked reference l ists of relevant articles and applied no language restrictions. Selection criteria We selected RCTs assessing the effects of whole grain foods or d iets containing whole grains compared to foods or diets with a s imilar composition, over a minimum of 12 weeks, on cardiovascular dise ase and related risk factors. Eligible for inclusion were heal thy adults, those at increased risk of CVD, or those previously diagnosed with CVD. Data collection and analysis Two review authors independently selected studies. Data wer e extracted and quality-checked by one review author and checked by a second review author. A second review author checked the analys es. We assessed treatment effect using mean difference in a fixe d- effect model and heterogeneity using the I 2 statistic and the Chi 2 test of heterogeneity. We assessed the overall quality of ev idence using GRADE with GRADEpro software.
Issue Date: 24-Aug-2017
Date of Acceptance: 1-Aug-2017
URI: http://hdl.handle.net/10044/1/54579
DOI: https://dx.doi.org/10.1002/14651858.CD005051.pub3
ISSN: 1469-493X
Publisher: Cochrane Collaboration
Journal / Book Title: Cochrane Database of Systematic Reviews
Volume: 8
Copyright Statement: © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
*Edible Grain
Cholesterol [blood]
Cholesterol, LDL [blood]
Coronary Disease [blood
*diet therapy]
Randomized Controlled Trials as Topic
Risk Factors
Humans
RANDOMIZED CONTROLLED-TRIAL
DEPENDENT DIABETIC-PATIENTS
DIETARY FIBER SUPPLEMENT
CORONARY-HEART-DISEASE
METABOLIC RISK-FACTORS
LOW-GLYCEMIC INDEX
OAT BETA-GLUCAN
MILDLY HYPERCHOLESTEROLEMIC MEN
PLACEBO-CONTROLLED TRIAL
FECAL STEROID-EXCRETION
Adult
Aged
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Edible Grain
Middle Aged
Triglycerides
11 Medical And Health Sciences
Publication Status: Published
Article Number: ARTN CD005051
Appears in Collections:Department of Medicine (up to 2019)