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Using Wolbachia for Dengue Control: Insights from Modelling.

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Title: Using Wolbachia for Dengue Control: Insights from Modelling.
Authors: Dorigatti, I
McCormack, C
Nedjati-Gilani, G
Ferguson, NM
Item Type: Journal Article
Abstract: Dengue is the most common arboviral infection of humans, responsible for a substantial disease burden across the tropics. Traditional insecticide-based vector-control programmes have limited effectiveness, and the one licensed vaccine has a complex and imperfect efficacy profile. Strains of the bacterium Wolbachia, deliberately introduced into Aedes aegyptimosquitoes, have been shown to be able to spread to high frequencies in mosquito populations in release trials, and mosquitoes infected with these strains show markedly reduced vector competence. Thus, Wolbachia represents an exciting potential new form of biocontrol for arboviral diseases, including dengue. Here, we review how mathematical models give insight into the dynamics of the spread of Wolbachia, the potential impact of Wolbachia on dengue transmission, and we discuss the remaining challenges in evaluation and development.
Issue Date: 25-Nov-2017
Date of Acceptance: 2-Nov-2017
URI: http://hdl.handle.net/10044/1/54478
DOI: https://dx.doi.org/10.1016/j.pt.2017.11.002
ISSN: 1471-5007
Publisher: Elsevier
Start Page: 102
End Page: 113
Journal / Book Title: Trends in Parasitology
Volume: 34
Issue: 2
Copyright Statement: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/K010174/1B
Keywords: 06 Biological Sciences
07 Agricultural And Veterinary Sciences
11 Medical And Health Sciences
Mycology & Parasitology
Publication Status: Published
Appears in Collections:School of Public Health