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Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study.

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Title: Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study.
Authors: Zheng, J-S
Sharp, SJ
Imamura, F
Koulman, A
Schulze, MB
Ye, Z
Griffin, J
Guevara, M
Huerta, JM
Kröger, J
Sluijs, I
Agudo, A
Barricarte, A
Boeing, H
Colorado-Yohar, S
Dow, C
Dorronsoro, M
Dinesen, PT
Fagherazzi, G
Franks, PW
Feskens, EJM
Kühn, T
Katzke, VA
Key, TJ
Khaw, K-T
De Magistris, MS
Mancini, FR
Molina-Portillo, E
Nilsson, PM
Olsen, A
Overvad, K
Palli, D
Quirós, JR
Rolandsson, O
Ricceri, F
Spijkerman, AMW
Slimani, N
Tagliabue, G
Tjonneland, A
Tumino, R
Van der Schouw, YT
Langenberg, C
Riboli, E
Forouhi, NG
Wareham, NJ
Item Type: Journal Article
Abstract: BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. METHODS: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. RESULTS: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. CONCLUSIONS: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.
Issue Date: 17-Nov-2017
Date of Acceptance: 27-Oct-2017
URI: http://hdl.handle.net/10044/1/54178
DOI: https://dx.doi.org/10.1186/s12916-017-0968-4
ISSN: 1741-7015
Publisher: BioMed Central
Journal / Book Title: BMC Medicine
Volume: 15
Issue: 1
Copyright Statement: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: P47328
Keywords: Even-chain
Glycaemic
Hepatic
Inflammation
Lipids
Metabolic markers
Odd-chain
Saturated fatty acids
Very-long-chain
11 Medical And Health Sciences
General & Internal Medicine
Publication Status: Published
Article Number: 203
Appears in Collections:School of Public Health