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Senescence and aging – causes, consequences, and therapeutic avenues

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Title: Senescence and aging – causes, consequences, and therapeutic avenues
Authors: McHugh, D
Gil, J
Item Type: Journal Article
Abstract: Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biological basis of aging, research suggests that targeting the aging process itself could ameliorate many age-related pathologies. Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease. In this regard, recent experimental evidence has shown that the genetic or pharmacological ablation of senescent cells extends life span and improves health span. Here, we review the cellular and molecular links between cellular senescence and aging and discuss the novel therapeutic avenues that this connection opens.
Issue Date: 7-Nov-2017
Date of Acceptance: 17-Oct-2017
URI: http://hdl.handle.net/10044/1/52021
DOI: https://dx.doi.org/10.1083/jcb.201708092
ISSN: 0021-9525
Publisher: Rockefeller University Press
Start Page: 65
End Page: 77
Journal / Book Title: Journal of Cell Biology
Volume: 217
Issue: 1
Copyright Statement: © 2018 McHugh and Gil This article is distributed under the terms of an Attribution– Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
Keywords: 06 Biological Sciences
11 Medical And Health Sciences
Developmental Biology
Publication Status: Published
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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