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Zebrafish Infection: from Pathogenesis to Cell Biology

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Title: Zebrafish Infection: from Pathogenesis to Cell Biology
Authors: Torraca, V
Mostowy, S
Item Type: Journal Article
Abstract: The study of host–pathogen interactions has illuminated fundamental research avenues in both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable, optically accessible, and present a fully functional innate immune system with macrophages and neutrophils that mimic their mammalian counterparts. A wide variety of pathogenic bacteria have been investigated using zebrafish models, providing unprecedented resolution of the cellular response to infection in vivo. In this review, we illustrate how zebrafish models have contributed to our understanding of cellular microbiology by providing an in vivo platform to study host–pathogen interactions from the single cell to whole animal level. We also highlight discoveries made from zebrafish infection that hold great promise for translation into novel therapies for humans.
Issue Date: 21-Nov-2017
Date of Acceptance: 6-Oct-2017
URI: http://hdl.handle.net/10044/1/52010
DOI: https://dx.doi.org/10.1016/j.tcb.2017.10.002
ISSN: 0962-8924
Publisher: Elsevier
Start Page: 143
End Page: 156
Journal / Book Title: Trends in Cell Biology
Volume: 28
Issue: 2
Copyright Statement: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: autophagy
bacterial infection
cellular microbiology
innate immunity
06 Biological Sciences
11 Medical And Health Sciences
Developmental Biology
Publication Status: Published online
Appears in Collections:Department of Medicine (up to 2019)