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Extracellular pH monitoring for use in closed-loop vagus nerve stimulation.

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Title: Extracellular pH monitoring for use in closed-loop vagus nerve stimulation.
Authors: Cork, SC
Eftekhar, A
Mirza, KB
Gardiner, JV
Bloom, SR
Toumazou, C
Item Type: Journal Article
Abstract: OBJECTIVE: Vagal nerve stimulation (VNS) has shown potential benefits for obesity treatment; however current devices lack physiological feedback, which limit their efficacy. Changes in extracellular pH (pH<sub>e</sub>) have shown to be correlated with neural activity, but have traditionally been measured with glass microelectrodes, which limit their in vivo applicability. APPROACH: Iridium oxide has previously been shown to be sensitive to fluctuations in pH and is biocompatible. Iridium oxide microelectrodes were inserted into the subdiaphragmatic vagus nerve of anaesthetised rats. Introduction of the gut hormone cholecystokinin (CCK) or distension of the stomach was used to elicit vagal nerve activity. MAIN RESULTS: iridium oxide microelectrodes have sufficient pH sensitivity to readily detect changes in pH<sub>e</sub> associated with both CCK and gastric distension. What's more, custom made Matlab script was able to use these changes in pH<sub>e</sub> to automatically trigger an implanted VNS device. SIGNIFICANCE: This is the first study to show pH<sub>e</sub> changes in peripheral nerves in vivo. Furthermore, the demonstration that iridium oxide microelectrodes are sufficiently pH sensitive as to measure changes in pH<sub>e</sub> associated with physiological stimuli means they have the potential to be integrated into closed-loop neurostimulating devices.
Issue Date: 26-Jul-2017
Date of Acceptance: 26-Jul-2017
URI: http://hdl.handle.net/10044/1/51866
DOI: https://dx.doi.org/10.1088/1741-2552/aa8239
ISSN: 1741-2552
Publisher: IOP Publishing
Journal / Book Title: Journal of Neural Engineering
Volume: 15
Copyright Statement: Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Sponsor/Funder: Commission of the European Communities
Biotechnology and Biological Sciences Research Council (BBSRC)
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: 319818
BB/L018268/1
EP/N002474/1
Keywords: Science & Technology
Technology
Life Sciences & Biomedicine
Engineering, Biomedical
Neurosciences
Engineering
Neurosciences & Neurology
iridium oxide
extracellular pH
neuromodulation
obesity
closed-loop control
vagal nerve stimulation (VNS)
ELECTRICAL-STIMULATION
MORBID-OBESITY
WEIGHT-LOSS
BRAIN
TRIAL
MICROELECTRODE
MODULATION
TRANSIENTS
RESPONSES
DOPAMINE
Closed-loop control
Extracellular pH
Neuromodulation
Obesity
Vagal nerve stimulation (VNS)
0903 Biomedical Engineering
1103 Clinical Sciences
1109 Neurosciences
Biomedical Engineering
Publication Status: Published
Article Number: 016001
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering
Department of Medicine
Faculty of Medicine



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