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Update in Interstitial Lung Disease 2016

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Title: Update in Interstitial Lung Disease 2016
Authors: Wells, AU
Maher, TM
Item Type: Journal Article
Abstract: Entomologically, metamorphosis is defined as the process of transformation from an immature form to an adult form. No better term exists for the coming of age of interstitial lung disease (ILD) in 2014. The pivotal trials of antifibrotic agents (1, 2) in idiopathic pulmonary fibrosis (IPF) changed the specialty irrevocably. For the first time, the diagnostic distinction between IPF and other forms of ILD matters therapeutically. The reappraisal of risks and benefits of invasive diagnostic procedures and the emerging data on the diagnostic accuracy of high-resolution computed tomography (HRCT) in key IPF subgroups has major implications for multidisciplinary practice. The efficacy of pirfenidone and nintedanib poses new challenges in trial design. The perceived need for earlier IPF diagnosis has led to increased interest in studies of “interstitial lung abnormalities” (ILAs) in elderly patients. Acute exacerbations of IPF are under renewed scrutiny, and the surge in Internet information on IPF has created its own problems regarding misinformation. Basic science research in IPF mechanisms, already an area of rapid development, has never seemed more relevant to future clinical developments. The changes within the ILD specialty are captured by the nature of articles published in 2016 in the Journal. IPF was either the primary focus or an important component in 15 of 21 ILD perspectives and original research articles. Sarcoidosis was the subject of two reports, and the remaining publications explored clinical and scientific issues in pulmonary fibrosis.
Issue Date: 21-May-2017
Date of Acceptance: 19-Apr-2017
URI: http://hdl.handle.net/10044/1/51709
DOI: https://dx.doi.org/10.1164/rccm.201702-0351UP
ISSN: 1073-449X
Publisher: American Thoracic Society
Start Page: 132
End Page: 138
Journal / Book Title: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume: 196
Issue: 2
Copyright Statement: © 2017 American Thoracic Society
Keywords: Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
IDIOPATHIC PULMONARY-FIBROSIS
DAILY HOME SPIROMETRY
EXTRACORPOREAL MEMBRANE-OXYGENATION
ACUTE RESPIRATORY-FAILURE
PRECISION MEDICINE
ACUTE EXACERBATION
DIAGNOSTIC YIELD
DISTAL AIRWAYS
ABNORMALITIES
PROGRESSION
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:National Heart and Lung Institute