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Urinary metabolic phenotyping of women with lower urinary tract symptoms

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Bray_LUTS_2017vII.docxAccepted version3.74 MBMicrosoft WordView/Open
Bray2017_SIvII.docxSupporting information696.65 kBMicrosoft WordView/Open
Title: Urinary metabolic phenotyping of women with lower urinary tract symptoms
Authors: Bray, R
Cacciatore, S
Jimenez, B
Cartwright, R
Digesu, A
Fernando, R
Holmes, E
Nicholson, JK
Bennett, PR
MacIntyre, DA
Khullar, V
Item Type: Journal Article
Abstract: Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance (1H NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynecology clinics (cases; n = 176) and healthy control women attending general gynecology clinics (n = 36). Despite high variation in the urine metabolome across the cohort, associations between urine metabolic profiles and BMI, parity, overactive bladder syndrome, frequency, straining, and bladder storage were identified using KODAMA (knowledge discovery by accuracy maximization). Four distinct urinary metabotypes were identified, one of which was associated with increased urinary frequency and low BMI. Urine from these patients was characterized by increased levels of isoleucine and decreased levels of hippurate. Our study suggests that metabolic profiling of urine samples from LUTS patients offers the potential to identify differences in underlying etiology, which may permit stratification of patient populations and the design of more personalized treatment strategies.
Issue Date: 22-Sep-2017
Date of Acceptance: 22-Sep-2017
URI: http://hdl.handle.net/10044/1/51226
DOI: https://dx.doi.org/10.1021/acs.jproteome.7b00568
ISSN: 1535-3893
Publisher: American Chemical Society
Start Page: 4208
End Page: 4216
Journal / Book Title: Journal of Proteome Research
Volume: 16
Issue: 11
Copyright Statement: Copyright © 2017 American Chemical Society
Keywords: KODAMA
LUTS
NMR
metabolic profiling
metabolomics
overactive bladder
06 Biological Sciences
03 Chemical Sciences
Biochemistry & Molecular Biology
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer