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Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels

Title: Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels
Authors: Zanchi, D
Meyer-Gerspach, AC
Suenderhauf, C
Janach, K
Le Roux, CW
Haller, S
Drewe, J
Beglinger, C
Wlnerhanssen, BK
Borgwardt, S
Item Type: Journal Article
Abstract: Depending on their protein content, single meals can rapidly influence the uptake of amino acids into the brain and thereby modify brain functions. The current study investigates the effects of two different amino acids on the human gut-brain system, using a multimodal approach, integrating physiological and neuroimaging data. In a randomized, placebo-controlled trial, L-tryptophan, L-leucine, glucose and water were administered directly into the gut of 20 healthy subjects. Functional MRI (fMRI) in a resting state paradigm (RS), combined with the assessment of insulin and glucose blood concentration, was performed before and after treatment. Independent component analysis with dual regression technique was applied to RS-fMRI data. Results were corrected for multiple comparisons. In comparison to glucose and water, L-tryptophan consistently modifies the connectivity of the cingulate cortex in the default mode network, of the insula in the saliency network and of the sensory cortex in the somatosensory network. L-leucine has lesser effects on these functional networks. L-tryptophan and L-leucine also modified plasma insulin concentration. Finally, significant correlations were found between brain modifications after L-tryptophan administration and insulin plasma levels. This study shows that acute L-tryptophan and L-leucine intake directly influence the brain networks underpinning the food-reward system and appetite regulation.
Issue Date: 20-Oct-2016
Date of Acceptance: 4-Oct-2016
URI: http://hdl.handle.net/10044/1/50235
DOI: https://dx.doi.org/10.1038/srep35727
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 6
Copyright Statement: © 2016 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: ONO Pharmaceuticals Co Ltd
Funder's Grant Number: N/A
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
GLUCAGON-LIKE PEPTIDE-1
SUBJECT DIFFUSION DATA
AMINO-ACIDS
FOOD-INTAKE
AD-LIBITUM
INTRADUODENAL INFUSION
SPATIAL STATISTICS
VOXELWISE ANALYSIS
CONNECTIVITY MRI
HEALTHY-MEN
Publication Status: Published
Article Number: ARTN 35727
Appears in Collections:Department of Medicine (up to 2019)