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A pilot evaluation of a computer-based psychometric test battery designed to detect impairment in patients with cirrhosis

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Title: A pilot evaluation of a computer-based psychometric test battery designed to detect impairment in patients with cirrhosis
Authors: Cook, NA
Kim, JU
Crossey, MM
Schembri, AJ
Harel, BT
Kimhofer, T
Taylor-Robinson, SD
Item Type: Journal Article
Abstract: Background: Psychometric testing is used to identify patients with cirrhosis who have developed hepatic encephalopathy (HE). Most batteries consist of a series of paper-and-pencil tests, which are cumbersome for most clinicians. A modern, easy-to-use, computer-based battery would be a helpful clinical tool, given that in its minimal form, HE has an impact on both patients’ quality of life and the ability to drive and operate machinery (with societal consequences). Aim: We compared the Cogstate™ computer battery testing with the Psychometric Hepatic Encephalopathy Score (PHES) tests, with a view to simplify the diagnosis. Methods: This was a prospective study of 27 patients with histologically proven cirrhosis. An analysis of psychometric testing was performed using accuracy of task performance and speed of completion as primary variables to create a correlation matrix. A stepwise linear regression analysis was performed with backward elimination, using analysis of variance. Results: Strong correlations were found between the international shopping list, international shopping list delayed recall of Cogstate and the PHES digit symbol test. The Shopping List Tasks were the only tasks that consistently had P values of <0.05 in the linear regression analysis. Conclusion: Subtests of the Cogstate battery correlated very strongly with the digit symbol component of PHES in discriminating severity of HE. These findings would indicate that components of the current PHES battery with the international shopping list tasks of Cogstate would be discriminant and have the potential to be used easily in clinical practice.
Issue Date: 6-Sep-2017
Date of Acceptance: 7-Jul-2017
URI: http://hdl.handle.net/10044/1/50088
DOI: https://dx.doi.org/10.2147/IJGM.S140197
ISSN: 1178-7074
Publisher: Dove Medical Press
Start Page: 281
End Page: 289
Journal / Book Title: International Journal of General Medicine
Volume: 2017
Issue: 10
Copyright Statement: This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Wellcome Trust
Medical Research Council (MRC)
Wellcome Trust
Funder's Grant Number: 097816/Z/11/B
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
hepatic encephalopathy
minimal hepatic encephalopathy
psychometric testing
Cogstate (TM)
Psychometric Hepatic Encephalopathy Score
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer