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Tunable semiconducting polymer nanoparticles with INDT-based conjugated polymers for photoacoustic molecular imaging

Title: Tunable semiconducting polymer nanoparticles with INDT-based conjugated polymers for photoacoustic molecular imaging
Authors: Stahl, T
Bofinger, R
Lam, I
Fallon, KJ
Johnson, P
Ogunlade, O
Vassileva, V
Pedley, RB
Beard, PC
Hailes, HC
Bronstein, H
Tabor, AB
Item Type: Journal Article
Abstract: Photoacoustic imaging combines both excellent spatial resolution with high contrast and specificity, without the need for patients to be exposed to ionizing radiation. This makes it ideal for the study of physiological changes occurring during tumorigenesis and cardiovascular disease. In order to fully exploit the potential of this technique, new exogenous contrast agents with strong absorbance in the near-infrared range, good stability and biocompatibility, are required. In this paper, we report the formulation and characterization of a novel series of endogenous contrast agents for photoacoustic imaging in vivo. These contrast agents are based on a recently reported series of indigoid π-conjugated organic semiconductors, coformulated with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, to give semiconducting polymer nanoparticles of about 150 nm diameter. These nanoparticles exhibited excellent absorption in the near-infrared region, with good photoacoustic signal generation efficiencies, high photostability, and extinction coefficients of up to three times higher than those previously reported. The absorption maximum is conveniently located in the spectral region of low absorption of chromophores within human tissue. Using the most promising semiconducting polymer nanoparticle, we have demonstrated wavelength-dependent differential contrast between vasculature and the nanoparticles, which can be used to unambiguously discriminate the presence of the contrast agent in vivo.
Issue Date: 31-May-2017
Date of Acceptance: 13-May-2017
URI: http://hdl.handle.net/10044/1/49575
DOI: https://dx.doi.org/10.1021/acs.bioconjchem.7b00185
ISSN: 1043-1802
Publisher: American Chemical Society
Start Page: 1734
End Page: 1740
Journal / Book Title: Bioconjugate Chemistry
Volume: 28
Issue: 6
Copyright Statement: © 2017 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry, Organic
Blood Vessels
Contrast Media
Molecular Imaging
Photoacoustic Techniques
Spectroscopy, Near-Infrared
0305 Organic Chemistry
0601 Biochemistry And Cell Biology
0304 Medicinal And Biomolecular Chemistry
Organic Chemistry
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer