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Real-time observation of fluid flows in tissue during stress relaxation using Raman spectroscopy

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Title: Real-time observation of fluid flows in tissue during stress relaxation using Raman spectroscopy
Authors: Parkes, M
Cann, P
Jeffers, J
Item Type: Journal Article
Abstract: This paper outlines a technique to measure fluid levels in articular cartilage tissue during an unconfined stress relaxation test. A time series of Raman spectrum were recorded during relaxation and the changes in the specific Raman spectral bands assigned to water and protein were monitored to determine the fluid content of the tissue. After 1000 s unconfined compression the fluid content of the tissue is reduced by an average of 3.9% ± 1.7%. The reduction in fluid content during compression varies between samples but does not significantly increase with increasing strain. Further development of this technique will allow mapping of fluid distribution and flows during dynamic testing making it a powerful tool to understand the role of interstitial fluid in the functional performance of cartilage.
Issue Date: 21-Jun-2017
Date of Acceptance: 13-Jun-2017
URI: http://hdl.handle.net/10044/1/49299
DOI: https://dx.doi.org/10.1016/j.jbiomech.2017.06.004
ISSN: 1873-2380
Publisher: Elsevier
Start Page: 261
End Page: 265
Journal / Book Title: Journal of Biomechanics
Volume: 60
Copyright Statement: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC-BY license (http://creativecommons.org/licenses/by/4.0/)
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/K027549/1
MMRE_P60111
Keywords: Cartilage
Compression testing
In-situ Raman
0903 Biomedical Engineering
1106 Human Movement And Sports Science
0913 Mechanical Engineering
Biomedical Engineering
Publication Status: Published
Appears in Collections:Mechanical Engineering
Faculty of Engineering