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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference

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Title: Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference
Authors: Goodship, THJ
Cook, HT
Fakhouri, F
Fervenza, FC
Fremeaux-Bacchi, V
Kavanagh, D
Nester, CM
Noris, M
Pickering, MC
De Cordoba, SR
Roumenina, LT
Sethi, S
Smith, RJH
Item Type: Journal Article
Abstract: In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) complement plays a primary role in disease pathogenesis. Herein we report the outcome of a 2015 Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference where key issues in the management of these 2 diseases were considered by a global panel of experts. Areas addressed included renal pathology, clinical phenotype and assessment, genetic drivers of disease, acquired drivers of disease, and treatment strategies. In order to help guide clinicians who are caring for such patients, recommendations for best treatment strategies were discussed at length, providing the evidence base underpinning current treatment options. Knowledge gaps were identified and a prioritized research agenda was proposed to resolve outstanding controversial issues.
Issue Date: 16-Dec-2016
Date of Acceptance: 20-Oct-2016
URI: http://hdl.handle.net/10044/1/49060
DOI: https://dx.doi.org/10.1016/j.kint.2016.10.005
ISSN: 0085-2538
Publisher: Elsevier
Start Page: 539
End Page: 551
Journal / Book Title: Kidney International
Volume: 91
Issue: 3
Copyright Statement: © 2016, International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Urology & Nephrology
anti-complement therapies
atypical hemolytic uremic syndrome
C3 glomerulopathy
complement
glomerulonephritis
kidney disease
DENSE-DEPOSIT DISEASE
COMPLEMENT FACTOR-H
ECULIZUMAB MAINTENANCE TREATMENT
MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
MACULAR DEGENERATION
RENAL-TRANSPLANTATION
IGA NEPHROPATHY
MESANGIOCAPILLARY GLOMERULONEPHRITIS
OXFORD CLASSIFICATION
ALTERNATIVE PATHWAY
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Department of Medicine (up to 2019)
Faculty of Medicine



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