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HIV treatment as prevention: models, data, and questions--towards evidence-based decision-making.

Title: HIV treatment as prevention: models, data, and questions--towards evidence-based decision-making.
Authors: HIV Modelling Consortium Treatment as Prevention Editorial Writing Group
Item Type: Journal Article
Abstract: Antiretroviral therapy (ART) for those infected with HIV can prevent onward transmission of infection, but biological efficacy alone is not enough to guide policy decisions about the role of ART in reducing HIV incidence. Epidemiology, economics, demography, statistics, biology, and mathematical modelling will be central in framing key decisions in the optimal use of ART. PLoS Medicine, with the HIV Modelling Consortium, has commissioned a set of articles that examine different aspects of HIV treatment as prevention with a forward-looking research agenda. Interlocking themes across these articles are discussed in this introduction. We hope that this article, and others in the collection, will provide a foundation upon which greater collaborations between disciplines will be formed, and will afford deeper insights into the key factors involved, to help strengthen the support for evidence-based decision-making in HIV prevention.
Issue Date: 10-Jul-2012
Date of Acceptance: 10-Jul-2012
URI: http://hdl.handle.net/10044/1/48994
DOI: https://dx.doi.org/10.1371/journal.pmed.1001259
ISSN: 1549-1277
Publisher: Public Library of Science
Journal / Book Title: PLOS Medicine
Volume: 9
Issue: 7
Copyright Statement: Public Domain. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (https://creativecommons.org/share-your-work/public-domain/cc0/).
Keywords: Antiretroviral Therapy, Highly Active
Clinical Trials as Topic
Decision Making
Evidence-Based Medicine
HIV Infections
Humans
Models, Biological
HIV Modelling Consortium Treatment as Prevention Editorial Writing Group
General & Internal Medicine
11 Medical And Health Sciences
Publication Status: Published
Conference Place: United States
Article Number: e1001259
Appears in Collections:School of Public Health