Respiratory syncytial virus infection: an innate perspective.

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Title: Respiratory syncytial virus infection: an innate perspective.
Authors: Johansson, C
Item Type: Journal Article
Abstract: Respiratory syncytial virus (RSV) is a common cause of upper respiratory tract infection in children and adults. However, infection with this virus sometimes leads to severe lower respiratory disease and is the major cause of infant hospitalisations in the developed world. Several risk factors such as baby prematurity and congenital heart disease are known to predispose towards severe disease but previously healthy, full-term infants can also develop bronchiolitis and viral pneumonia during RSV infection. The causes of severe disease are not fully understood but may include dysregulation of the immune response to the virus, resulting in excessive recruitment and activation of innate and adaptive immune cells that can cause damage. This review highlights recent discoveries on the balancing act of immune-mediated virus clearance versus immunopathology during RSV infection.
Issue Date: 21-Dec-2016
Date of Acceptance: 1-Dec-2016
URI: http://hdl.handle.net/10044/1/48183
DOI: https://dx.doi.org/10.12688/f1000research.9637.1
ISSN: 2046-1402
Publisher: F1000Research
Journal / Book Title: F1000Research
Volume: 5
Copyright Statement: © 2016 Johansson C. This is an open access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Rosetrees Trust
National Heart and Lung Institute Foundation
Funder's Grant Number: G0800311
M370
Spiros Makris
Keywords: RSV
immune response to RSV
immune-mediated virus clearance
immunopathology
lower respiratory disease
respiratory syncytial virus
Publication Status: Published
Conference Place: England
Article Number: 2898
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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