39
IRUS Total
Downloads
  Altmetric

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

File Description SizeFormat 
Clulow_MainArticle_Revised#2_final.docxAccepted version3.76 MBMicrosoft WordView/Open
c6cc08797c.pdfPublished version3.07 MBAdobe PDFView/Open
Title: Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
Authors: Clulow, JA
Storck, EM
Lanyon-Hogg, T
Kalesh, KA
Jones, LH
Tate, EW
Item Type: Journal Article
Abstract: Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.
Issue Date: 25-Apr-2017
Date of Acceptance: 13-Apr-2017
URI: http://hdl.handle.net/10044/1/48122
DOI: https://dx.doi.org/10.1039/c6cc08797c
ISSN: 1364-548X
Publisher: Royal Society of Chemistry
Start Page: 5182
End Page: 5185
Journal / Book Title: Chemical Communications
Volume: 53
Copyright Statement: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence
Sponsor/Funder: Cancer Research UK
Funder's Grant Number: C29637/A20781
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
NF-KAPPA-B
PROTEIN LIPIDATION
EPITHELIAL-CELLS
GENE-EXPRESSION
ISOTHIOCYANATES
MECHANISMS
APOPTOSIS
CHEMOPREVENTION
INHIBITION
PREVENTION
Organic Chemistry
03 Chemical Sciences
Publication Status: Published
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Chemical Engineering
Faculty of Natural Sciences